Downing J W, Leary W P, White E S
Br J Anaesth. 1977 Mar;49(3):251-5. doi: 10.1093/bja/49.3.251.
A new thebaine derivative, buprenorphine, 0.6 mg, was compared with morphine 15 mg in a double-blind trial, in patients recovering from elective Caesarean section. Within 1 h of administration analgesia was obtained with both drugs and was sustained for 7-8 h with buprenorphine, and 3-4 h with morphine. Buprenorphine caused a greater decrease in diastolic arterial pressure than did morphine, but arterial systolic pressure and heart rate were not influenced by either drug. No serious side-effects were encountered in this study.
在一项双盲试验中，将一种新的蒂巴因衍生物——0.6毫克丁丙诺啡，与15毫克吗啡，在择期剖宫产术后恢复的患者中进行了比较。给药后1小时内，两种药物均获得了镇痛效果，丁丙诺啡的镇痛效果持续7 - 8小时，吗啡的镇痛效果持续3 - 4小时。丁丙诺啡比吗啡导致舒张压下降幅度更大，但两种药物对动脉收缩压和心率均无影响。本研究未发现严重副作用。
