Kay B
Br J Anaesth. 1978 Jun;50(6):605-9. doi: 10.1093/bja/50.6.605.
A double-blind, between-patient comparison has been made of the effects of morphine 10 mg i.v. and buprenorphine 0.3 mg i.v. on the prevention of pain after operation. The drugs were given by the anaesthetist at the end of the operation, and the onset and severity of pain were assessed by a trained nurse. Both drugs caused a significant delay in the appearance of severe pain when compared with the control group, but with buprenorphine the mean delay of 10.5 h was more than twice that of morphine. The only side-effect to occur more frequently after administration of the analgesics was drowsiness, the incidence being greater after buprenorphine than after morphine.
已对静脉注射10毫克吗啡和静脉注射0.3毫克丁丙诺啡预防术后疼痛的效果进行了双盲、患者间比较。药物由麻醉师在手术结束时给予，疼痛的发作和严重程度由一名经过培训的护士进行评估。与对照组相比，两种药物均使重度疼痛出现的时间显著延迟，但使用丁丙诺啡时，平均延迟10.5小时，是使用吗啡时的两倍多。使用镇痛药后更频繁出现的唯一副作用是嗜睡，丁丙诺啡用药后的发生率高于吗啡用药后。
