Diagnosis and Treatment Center of Breast Diseases, Shantou Affiliated Hospital, Sun Yat-sen University, Shantou 515031, People's Republic of China; Department of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, People's Republic of China.
Diagnosis and Treatment Center of Breast Diseases, Shantou Affiliated Hospital, Sun Yat-sen University, Shantou 515031, People's Republic of China.
Semin Cancer Biol. 2021 Oct;75:116-126. doi: 10.1016/j.semcancer.2020.12.019. Epub 2021 Jan 6.
Non-coding RNAs (ncRNAs) are functional RNAs with limited or no protein-coding ability. These interact with their target molecules and participate in the precise regulation of disease development. Metabolic reprogramming is a hallmark in cancer, and is considered essential in meeting increased macromolecular biosynthesis and energy generation of tumors. Recent studies have revealed the involvement of ncRNAs in several metabolic regulations of cancer through direct modulation of metabolic enzyme activities or participation of metabolism-related signaling pathways. Elucidation of how ncRNAs regulate metabolic reprogramming of cancers has opened up a novel intention to understand the mechanism of metabolic rewiring and also the opportunities of utilizing ncRNA-based therapeutics for targeting the metabolism in cancer treatment.
非编码 RNA（ncRNA）是具有有限或无蛋白质编码能力的功能性 RNA。这些 RNA 与它们的靶分子相互作用，并参与疾病发展的精确调控。代谢重编程是癌症的一个标志，被认为是满足肿瘤中大分子生物合成和能量产生增加所必需的。最近的研究表明，ncRNA 通过直接调节代谢酶活性或参与代谢相关信号通路，参与癌症的几种代谢调控。阐明 ncRNA 如何调节癌症的代谢重编程，为理解代谢重排的机制以及利用基于 ncRNA 的治疗方法靶向癌症治疗中的代谢提供了新的思路。
Zotero 插件