• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

非编码RNA介导的非小细胞肺癌中铁死亡的表观遗传修饰（综述）

Non‑coding RNA‑mediated epigenetic modification of ferroptosis in non‑small cell lung cancer (Review).

作者信息

Wang Yumin, Fleishman Joshua S, Li Yulin, Cao Yuwei, Wei Haidong, Zhang Zhe, Chen Jichao, Ding Mingchao

机构信息

Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, P.R. China.

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, New York, NY 11439, USA.

出版信息

Int J Oncol. 2025 Jan;66(1). doi: 10.3892/ijo.2024.5714. Epub 2024 Dec 13.

DOI:10.3892/ijo.2024.5714
PMID:39670309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11684792/
Abstract

Ferroptosis is a novel form of regulated cell death that plays a key role in inhibiting tumor malignancy. The ferroptosis signalling cascade provides new opportunities for lung cancer therapy. Non‑coding RNA (ncRNA)‑mediated epigenetic modification can influence the vulnerability of cancer cells to ferroptosis in non‑small‑cell lung cancer (NSCLC). The present review describes the core molecular mechanisms underlying ferroptosis and the role of epigenetic mechanisms in regulating ferroptosis in NSCLC, as well as developments in understanding the ncRNA‑induced mechanisms that affect ferroptosis in NSCLC. The present review aimed to enhance understanding of the epigenetic mechanisms mediated by ncRNAs that modulate ferroptosis in NSCLC, highlighting a novel therapeutic strategy for NSCLC via the ncRNA‑ferroptosis axis.

摘要

铁死亡是一种新型的程序性细胞死亡形式，在抑制肿瘤恶性进展中起关键作用。铁死亡信号级联反应为肺癌治疗提供了新的机遇。非编码RNA（ncRNA）介导的表观遗传修饰可影响非小细胞肺癌（NSCLC）中癌细胞对铁死亡的易感性。本综述描述了铁死亡的核心分子机制以及表观遗传机制在调节NSCLC中铁死亡中的作用，以及在理解ncRNA诱导的影响NSCLC中铁死亡的机制方面的进展。本综述旨在增进对ncRNA介导的调节NSCLC中铁死亡的表观遗传机制的理解，突出通过ncRNA-铁死亡轴治疗NSCLC的新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2616/11684792/075baab37d3c/ijo-66-01-05714-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2616/11684792/2600460a1841/ijo-66-01-05714-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2616/11684792/bafa76807a8d/ijo-66-01-05714-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2616/11684792/35d6147ddfde/ijo-66-01-05714-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2616/11684792/22a48a1635a1/ijo-66-01-05714-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2616/11684792/075baab37d3c/ijo-66-01-05714-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2616/11684792/2600460a1841/ijo-66-01-05714-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2616/11684792/bafa76807a8d/ijo-66-01-05714-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2616/11684792/35d6147ddfde/ijo-66-01-05714-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2616/11684792/22a48a1635a1/ijo-66-01-05714-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2616/11684792/075baab37d3c/ijo-66-01-05714-g04.jpg

相似文献

1
Non‑coding RNA‑mediated epigenetic modification of ferroptosis in non‑small cell lung cancer (Review).非编码RNA介导的非小细胞肺癌中铁死亡的表观遗传修饰（综述）
Int J Oncol. 2025 Jan;66(1). doi: 10.3892/ijo.2024.5714. Epub 2024 Dec 13.
2
Regulating ferroptosis by non-coding RNAs in hepatocellular carcinoma.非编码 RNA 调控肝细胞癌中的铁死亡。
Biol Direct. 2024 Sep 12;19(1):80. doi: 10.1186/s13062-024-00530-w.
3
Epigenetic modification of ferroptosis by non-coding RNAs in cancer drug resistance.非编码 RNA 对癌症耐药性中铁死亡的表观遗传修饰。
Mol Cancer. 2024 Aug 27;23(1):177. doi: 10.1186/s12943-024-02088-7.
4
LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis.长链非编码 RNA ITGB2-AS1 通过激活 FOSL2/NAMPT 轴抑制铁死亡来促进非小细胞肺癌对顺铂的耐药性。
Cancer Biol Ther. 2023 Dec 31;24(1):2223377. doi: 10.1080/15384047.2023.2223377.
5
Roles of noncoding RNAs in metastasis of nonsmall cell lung cancer: A mini review.非编码RNA在非小细胞肺癌转移中的作用：一篇综述
J Cancer Res Ther. 2015 Aug;11 Suppl 1:C7-10. doi: 10.4103/0973-1482.163831.
6
Regulation of tumorigenesis and ferroptosis in non-small cell lung cancer by a novel BBOX1-AS1/miR-326/PROM2 axis.新型 BBOX1-AS1/miR-326/PROM2 轴调控非小细胞肺癌的发生发展和铁死亡。
Mol Cell Biochem. 2024 Aug;479(8):2143-2155. doi: 10.1007/s11010-023-04837-6. Epub 2023 Aug 28.
7
Ferroptosis in Cancer: Epigenetic Control and Therapeutic Opportunities.铁死亡在癌症中的作用：表观遗传调控与治疗机会
Biomolecules. 2024 Nov 13;14(11):1443. doi: 10.3390/biom14111443.
8
The emerging role of noncoding RNAs in the EGFR signaling pathway in lung cancer.非编码 RNA 在肺癌中 EGFR 信号通路中的新兴作用。
Pathol Res Pract. 2024 Jan;253:155016. doi: 10.1016/j.prp.2023.155016. Epub 2023 Dec 5.
9
Circ_0082374 Promotes the Tumorigenesis and Suppresses Ferroptosis in Non-small Cell Lung Cancer by Up-Regulating GPX4 Through Sequestering miR-491-5p.环状RNA_0082374通过隔离miR-491-5p上调谷胱甘肽过氧化物酶4促进非小细胞肺癌的肿瘤发生并抑制铁死亡
Mol Biotechnol. 2025 Feb;67(2):484-495. doi: 10.1007/s12033-024-01059-z. Epub 2024 Mar 4.
10
Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells.长链非编码 RNA 肺癌相关转录本 1 通过 microRNA-34a-5p 介导的 GTP 环水解酶 1 下调调控肺癌细胞中的铁死亡。
Int J Oncol. 2024 Jun;64(6). doi: 10.3892/ijo.2024.5652. Epub 2024 May 17.

引用本文的文献

1
Whole transcriptome sequencing to uncover CircRNA expression patterns linked to schizophrenia pathogenesis.全转录组测序以揭示与精神分裂症发病机制相关的环状RNA表达模式。
Eur J Med Res. 2025 Jul 15;30(1):626. doi: 10.1186/s40001-025-02899-4.
2
Reciprocal regulation between m6 A modifications and non-coding RNAs: emerging roles in cancer therapeutic resistance.m6A修饰与非编码RNA之间的相互调控：在癌症治疗耐药性中的新作用
Discov Oncol. 2025 May 25;16(1):920. doi: 10.1007/s12672-025-02641-w.
3
C-type lectin-like molecule-1 as a diagnostic, prognostic, and therapeutic marker in leukemia.

本文引用的文献

1
NFE2L2 and ferroptosis resistance in cancer therapy.NFE2L2与癌症治疗中的铁死亡抗性
Cancer Drug Resist. 2024 Oct 25;7:41. doi: 10.20517/cdr.2024.123. eCollection 2024.
2
Regulating ferroptosis by non-coding RNAs in hepatocellular carcinoma.非编码 RNA 调控肝细胞癌中的铁死亡。
Biol Direct. 2024 Sep 12;19(1):80. doi: 10.1186/s13062-024-00530-w.
3
Epigenetic modification of ferroptosis by non-coding RNAs in cancer drug resistance.非编码 RNA 对癌症耐药性中铁死亡的表观遗传修饰。
C型凝集素样分子-1作为白血病的诊断、预后及治疗标志物
Mol Biol Rep. 2025 May 16;52(1):464. doi: 10.1007/s11033-025-10527-x.
4
o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis.o8G修饰的环状KIAA1797通过抑制铜死亡促进肺癌发展。
J Exp Clin Cancer Res. 2025 Apr 2;44(1):110. doi: 10.1186/s13046-025-03365-z.
5
Vitamin D3 and its active form calcitriol suppress erythroleukemia through upregulation of CHAC1 and downregulation of NOTCH1.维生素D3及其活性形式骨化三醇通过上调CHAC1和下调NOTCH1来抑制红白血病。
Med Oncol. 2025 Mar 27;42(5):138. doi: 10.1007/s12032-025-02695-4.
Mol Cancer. 2024 Aug 27;23(1):177. doi: 10.1186/s12943-024-02088-7.
4
CircPDSS1 (hsa_circ_0017998) silencing induces ferroptosis in non-small-cell lung cancer cells by modulating the miR-137/SLC7A11/GPX4/GCLC axis.环状 RNA PDSS1(hsa_circ_0017998) 通过调节 miR-137/SLC7A11/GPX4/GCLC 轴诱导非小细胞肺癌细胞发生铁死亡。
Toxicol In Vitro. 2024 Aug;99:105887. doi: 10.1016/j.tiv.2024.105887. Epub 2024 Jun 28.
5
Inducing ferroptosis by traditional medicines: a novel approach to reverse chemoresistance in lung cancer.传统药物诱导铁死亡：一种逆转肺癌化疗耐药性的新方法。
Front Pharmacol. 2024 May 23;15:1290183. doi: 10.3389/fphar.2024.1290183. eCollection 2024.
6
Sanggenol L induces ferroptosis in non-small cell lung cancer cells via regulating the miR-26a-1-3p/MDM2/p53 signaling pathway.桑根醇 L 通过调控 miR-26a-1-3p/MDM2/p53 信号通路诱导非小细胞肺癌细胞发生铁死亡。
Biochem Pharmacol. 2024 Aug;226:116345. doi: 10.1016/j.bcp.2024.116345. Epub 2024 Jun 8.
7
PURPL Promotes M2 Macrophage Polarization in Lung Cancer by Regulating RBM4/xCT Signaling.PURPL 通过调控 RBM4/xCT 信号促进肺癌 M2 型巨噬细胞极化。
Crit Rev Eukaryot Gene Expr. 2024;34(5):59-68. doi: 10.1615/CritRevEukaryotGeneExpr.2024052788.
8
The EGR1/miR-139/NRF2 axis orchestrates radiosensitivity of non-small-cell lung cancer via ferroptosis.EGR1/miR-139/NRF2 轴通过铁死亡调控非小细胞肺癌的放射敏感性。
Cancer Lett. 2024 Jul 28;595:217000. doi: 10.1016/j.canlet.2024.217000. Epub 2024 May 29.
9
Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells.长链非编码 RNA 肺癌相关转录本 1 通过 microRNA-34a-5p 介导的 GTP 环水解酶 1 下调调控肺癌细胞中的铁死亡。
Int J Oncol. 2024 Jun;64(6). doi: 10.3892/ijo.2024.5652. Epub 2024 May 17.
10
Exosomal lncRNA ROR1-AS1 from cancer-associated fibroblasts inhibits ferroptosis of lung cancer cells through the IGF2BP1/SLC7A11 signal axis.肿瘤相关成纤维细胞来源的外泌体 lncRNA ROR1-AS1 通过 IGF2BP1/SLC7A11 信号轴抑制肺癌细胞铁死亡。
Cell Signal. 2024 Aug;120:111221. doi: 10.1016/j.cellsig.2024.111221. Epub 2024 May 8.