使用丙磺舒技术比较诺米芬辛和氯米帕明治疗单相抑郁症的对照研究。
Controlled study comparing nomifensine and clomipramine in unipolar depression, using the probenecid technique.
作者信息
Van Scheyen J D, Van Praag H M, Korf J
出版信息
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):179S-184S. doi: 10.1111/j.1365-2125.1977.tb05749.x.
Abstract
- Central dopamine turnover may be lowered in patients with unipolar endogenous depression particularly when associated with retardation. 2. Nomifensine selectively activates the central dopaminergic system and may be of special therapeutic value in patients with motor inhibition. 3. A double-blind comparison of clomipramine and nomifensine was carried out in patients with recurrent unipolar depression. Biochemical and clinical assessments were carried out weekly for 4 weeks. 4. The mean homovanillic acid level in cisternal liquor of those patients who responded to nomifensine, was significantly lower than the mean level of the total group. 5. The factor "retardation" on the Hamilton Depression Scale was improved more with nomifensine than with clomipramine.
摘要
- 单相内源性抑郁症患者中枢多巴胺周转率可能降低，尤其是伴有迟缓症状时。2. 诺米芬辛可选择性激活中枢多巴胺能系统，对有运动抑制症状的患者可能具有特殊治疗价值。3. 对复发性单相抑郁症患者进行了氯米帕明和诺米芬辛的双盲对照研究。每周进行生化和临床评估，持续4周。4. 对诺米芬辛有反应的患者脑池液中高香草酸平均水平显著低于总组平均水平。5. 在汉密尔顿抑郁量表上，“迟缓”因子用诺米芬辛治疗比用氯米帕明改善得更多。
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