诺米芬辛与安慰剂的比较。
Comparison of nomifensine and placebo.
作者信息
Taeuber K
出版信息
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):209S-213S. doi: 10.1111/j.1365-2125.1977.tb05754.x.
Abstract
- Methodological reasons are discussed which make placebo-controlled trials on antidepressant drugs necessary. 2. The ethical problem of treating a sick patient with an inactive compound are shown to have an impact on the methodology of such trials. 3. Three double-blind placebo-controlled trials with nomifensine are reviewed; one in neurotic depression, one in psychotic depression and one in geriatric patients showing depressive symptoms. 4. In all three trials the effect of nomifensine has been shown to be superior to that of placebo.
摘要
- 讨论了使抗抑郁药物的安慰剂对照试验成为必要的方法学原因。2. 用无活性化合物治疗患病患者的伦理问题被证明会对此类试验的方法学产生影响。3. 回顾了三项使用诺米芬辛的双盲安慰剂对照试验；一项针对神经症性抑郁症患者，一项针对精神病性抑郁症患者，一项针对有抑郁症状的老年患者。4. 在所有三项试验中，诺米芬辛的效果均已证明优于安慰剂。
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