Läuger P
Department of Biology, University of Konstanz, Federal Republic of Germany.
Biophys J. 1988 Jan;53(1):53-65. doi: 10.1016/S0006-3495(88)83065-0.
This paper describes an analysis of microscopic models for the coupling between ion flow and rotation of bacterial flagella. In model I it is assumed that intersecting half-channels exist on the rotor and the stator and that the driving ion is constrained to move together with the intersection site. Model II is based on the assumption that ion flow drives a cycle of conformational transitions in a channel-like stator subunit that are coupled to the motion of the rotor. Analysis of both mechanisms yields closed expressions relating the torque M generated by the flagellar motor to the rotation rate v. Model I (and also, under certain assumptions, model II) accounts for the experimentally observed linear relationship between M and v. The theoretical equations lead to predictions on the relationship between rotation rate and driving force which can be tested experimentally.
本文描述了对离子流与细菌鞭毛旋转耦合的微观模型的分析。在模型I中，假设转子和定子上存在相交的半通道，并且驱动离子被限制与相交位点一起移动。模型II基于这样的假设，即离子流驱动类似通道的定子亚基中的构象转变循环，这些转变与转子的运动相耦合。对这两种机制的分析都得出了将鞭毛马达产生的扭矩M与旋转速率v相关联的封闭表达式。模型I（在某些假设下，模型II也是如此）解释了实验观察到的M与v之间的线性关系。理论方程得出了关于旋转速率与驱动力之间关系的预测，这些预测可以通过实验进行检验。
