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作为研究牙周病原体的实验模型。

as an experimental model for studying periodontopathogens.

作者信息

Santos Thaís Aguiar, Scorzoni Liliana, Santos Aline de Castro, Junqueira Juliana Campos, Anbinder Ana Lia

机构信息

Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, SP, Brazil.

出版信息

J Indian Soc Periodontol. 2020 Nov-Dec;24(6):593-596. doi: 10.4103/jisp.jisp_631_19. Epub 2020 Sep 21.

DOI:10.4103/jisp.jisp_631_19
PMID:33424181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7781244/
Abstract

In the present study, was evaluated as a potential infection model for periodontal bacteria, more specifically, , , and . All the bacteria evaluated were pathogenic to , causing their death in a concentration-dependent manner, and a decrease in their hemocyte count. Moreover, it was possible to recover the bacteria from the larvae hemolymph and determine the colony-forming units per larvae. is an effective model that may help to better understand the host-microbe interactions in periodontics.

摘要

在本研究中，[具体生物名称]被评估为牙周细菌的潜在感染模型，更具体地说，是[细菌名称1]、[细菌名称2]和[细菌名称3]的潜在感染模型。所有评估的细菌对[宿主名称]都具有致病性，以浓度依赖的方式导致其死亡，并使其血细胞计数下降。此外，有可能从幼虫血淋巴中回收细菌并确定每个幼虫的菌落形成单位。[具体生物名称]是一个有效的模型，可能有助于更好地理解牙周病学中宿主与微生物的相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9447/7781244/cd9dd7a65c42/JISP-24-593-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9447/7781244/567c566e29f6/JISP-24-593-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9447/7781244/58cbf5895976/JISP-24-593-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9447/7781244/cd9dd7a65c42/JISP-24-593-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9447/7781244/567c566e29f6/JISP-24-593-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9447/7781244/58cbf5895976/JISP-24-593-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9447/7781244/cd9dd7a65c42/JISP-24-593-g003.jpg

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本文引用的文献

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Recent Advances in the Use of Model to Study Immune Responses against Human Pathogens.利用模型研究针对人类病原体的免疫反应的最新进展。
J Fungi (Basel). 2018 Nov 27;4(4):128. doi: 10.3390/jof4040128.
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Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.牙周炎：2017 年牙周病和种植体周围疾病分类世界研讨会工作组 2 的共识报告。
J Clin Periodontol. 2018 Jun;45 Suppl 20:S162-S170. doi: 10.1111/jcpe.12946.
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Galleria mellonella infection models for the study of bacterial diseases and for antimicrobial drug testing.
PLoS One. 2022 Sep 29;17(9):e0274120. doi: 10.1371/journal.pone.0274120. eCollection 2022.
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Effects of α and β-adrenergic signaling on innate immunity and Porphyromonas gingivalis virulence in an invertebrate model.α 和 β-肾上腺素能信号对无脊椎动物模型中固有免疫和牙龈卟啉单胞菌毒力的影响。
Virulence. 2022 Dec;13(1):1614-1630. doi: 10.1080/21505594.2022.2123302.
用于研究细菌病和抗菌药物测试的金龟子幼虫感染模型。
Virulence. 2016 Apr 2;7(3):214-29. doi: 10.1080/21505594.2015.1135289. Epub 2016 Jan 5.
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Russell and Burch's 3Rs then and now: the need for clarity in definition and purpose.拉塞尔和伯奇的3R原则：过去与现在，定义和目的需清晰明确。
J Am Assoc Lab Anim Sci. 2015 Mar;54(2):120-32.
5
Superoxide production in Galleria mellonella hemocytes: identification of proteins homologous to the NADPH oxidase complex of human neutrophils.大蜡螟血细胞中超氧化物的产生：与人中性粒细胞NADPH氧化酶复合物同源的蛋白质的鉴定。
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