Ali Khan Barkat, Ullah Shafi, Khan M Khalid, Alshahrani Sultan M, Braga Valdir A
Faculty of Pharmacy, Gomal University, Dera Ismail Khan 29500, Pakistan.
College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Saudi Pharm J. 2020 Dec;28(12):1842-1850. doi: 10.1016/j.jsps.2020.11.011. Epub 2020 Nov 23.
The main aim of the topically applied drugs is to provide local drug contact to the skin and minimize general absorption of drugs. (OB) is popular for folk medicines, having official acceptance in many countries. The aim of this study was to formulate and evaluate the efficacy of topical application of OB-based emulgel on wound healing in animal model. The prepared formulations (OB emulgel) were assessed for FTIR analysis, stability studies, physical appearance, rheological behavior, spreadability, patch/sensitivity test and drug release. The wound healing effect was evaluated and compared with commercially available Silver Sulfadiazine cream Quench® in wound-induced rabbits by macroscopic and histopathological evidence. The OB extract/drug was compatible with the selected polymer and other excipients and indicated the suitability of the polymers/excipients for preparation of topical emulgel. The formulated OB emulgel exhibited good physical properties. The release profile of emulgel was satisfactory and released 81.71 ± 1.7% of the drug in 250 min. wound healing studies showed that OB emulgel exhibited the highest percent wound contraction similar to the commercial product (p > 0.05). This activity was statistically significant (p < 0.05) in comparison to control. Histopathological assessment showed marked improvement in the skin histological architecture after 16 days of OB emulgel treatment. In conclusion, the data demonstrated here signify the prospective of 5% OB emulgel as an innovative therapeutic approach in wound healing.
局部应用药物的主要目的是使药物与皮肤局部接触，并尽量减少药物的全身吸收。（OB）在民间药物中很受欢迎，在许多国家已获得官方认可。本研究的目的是制备并评估基于OB的乳胶在动物模型中对伤口愈合的局部应用效果。对制备的制剂（OB乳胶）进行傅里叶变换红外光谱（FTIR）分析、稳定性研究、外观、流变学行为、铺展性、贴片/敏感性测试和药物释放评估。通过宏观和组织病理学证据，评估伤口愈合效果，并与市售的磺胺嘧啶银乳膏Quench®在伤口诱导的兔子中进行比较。OB提取物/药物与所选聚合物和其他辅料相容，表明聚合物/辅料适用于制备局部乳胶。所制备的OB乳胶表现出良好的物理性质。乳胶的释放曲线令人满意，在250分钟内释放了81.71±1.7%的药物。伤口愈合研究表明，OB乳胶表现出与市售产品相似的最高伤口收缩百分比（p>0.05）。与对照组相比，该活性具有统计学意义（p<0.05）。组织病理学评估显示，在OB乳胶治疗16天后，皮肤组织学结构有明显改善。总之，此处展示的数据表明5%OB乳胶作为伤口愈合的一种创新治疗方法具有前景。
