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利用叶提取物绿色合成银纳米颗粒以应对物种生长及其他危险病原体。

Green synthesis of silver nanoparticles by leaf extract to tackle growth of species and other perilous pathogens.

作者信息

Raghava Sri, Munnene Mbae Kenneth, Umesha S

机构信息

Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India.

出版信息

Saudi J Biol Sci. 2021 Jan;28(1):495-503. doi: 10.1016/j.sjbs.2020.10.034. Epub 2020 Oct 28.

DOI:10.1016/j.sjbs.2020.10.034
PMID:33424332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7785426/
Abstract

Novel approaches are obligatory to treat chronic intracellular bacterial infectious diseases like Brucellosis specifically, are very complicated to deal with. The aim of the study to take upon nanotechnology approach to exploit the efficacy of the synthesized nanoparticles, to overcome barriers for treatment of species and other pathogens. Present study used extract as reductant of silver ions for synthesis of silver nanoparticles for the first time. Rh-AgNP's was characterized by UV-visible spectroscopy, DLS, FT-IR, SEM, EDS, TEM and XRD. Radical scavenging, antibrucellosis, bactericidal activity was evaluated. Clinical application was assessed by Rate of haemolysis, fibrinolytic and Hemagglutination activity. UV-visible spectrum of synthesized Rh-AgNP's showed maximum peak at 440 nm indicating the formation of nanoparticles. TEM showed that the average particle size of nanoparticles 51 nm with spherical shape, DLS depicted monodisperse state in water; EDS confirmed the presence of silver metal. Rh-AgNP's exhibited potential antibrucellosis activity against and effective inhibition at 800 μg/mL. The bio-compatibility of Rh-AgNP's was established by rate of haemolysis, hemagglutination and fibrinolytic activity. For the first time it has been proved that Rh-AgNP's have efficacy as antimicrobial agent with potential application in the biological domain.

摘要

新型方法对于特异性治疗诸如布鲁氏菌病等慢性细胞内细菌感染性疾病是必不可少的，但处理起来非常复杂。本研究的目的是采用纳米技术方法来利用合成纳米颗粒的功效，以克服治疗该菌种和其他病原体的障碍。本研究首次使用提取物作为银离子的还原剂来合成银纳米颗粒。通过紫外可见光谱、动态光散射、傅里叶变换红外光谱、扫描电子显微镜、能谱分析、透射电子显微镜和X射线衍射对Rh-AgNP进行了表征。评估了自由基清除、抗布鲁氏菌病和杀菌活性。通过溶血率、纤维蛋白溶解和血凝活性评估了临床应用。合成的Rh-AgNP的紫外可见光谱在440nm处显示出最大峰值，表明纳米颗粒的形成。透射电子显微镜显示纳米颗粒的平均粒径为51nm，呈球形，动态光散射表明在水中呈单分散状态；能谱分析证实了银金属的存在。Rh-AgNP对布鲁氏菌表现出潜在的抗布鲁氏菌病活性，在800μg/mL时具有有效抑制作用。通过溶血率、血凝和纤维蛋白溶解活性确定了Rh-AgNP的生物相容性。首次证明Rh-AgNP作为抗菌剂具有功效，在生物领域具有潜在应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/24112320f4cf/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/62150ea05dba/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/eebd2cf07214/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/5c560720b55d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/f6a81c4912e7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/115c815bd8a8/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/49389fef78af/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/25c5856928ac/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/9b8b27c9ee90/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/a0ee336f0da7/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/90cdf32b1de5/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/24112320f4cf/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/62150ea05dba/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/eebd2cf07214/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/5c560720b55d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/f6a81c4912e7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/115c815bd8a8/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/49389fef78af/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/25c5856928ac/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/9b8b27c9ee90/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/a0ee336f0da7/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/90cdf32b1de5/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e973/7785426/24112320f4cf/gr11.jpg

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