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负载于二氧化硅纳米颗粒和银纳米颗粒上的环丙沙星对……抑制作用的生物活性比较

Biological activity comparison between ciprofloxacin loaded to silica nanoparticles and silver nanoparticles for the inhibition of .

作者信息

Jaber Saif Aldeen, Saadh Mohamed J

机构信息

Department of Pharmacy, Faculty of Pharmacy, Middle East University, Amman, Jordan.

Applied Science Research Centre, Applied Science Private University, Amman, Jordan.

出版信息

Vet World. 2024 Feb;17(2):407-412. doi: 10.14202/vetworld.2024.407-412. Epub 2024 Feb 20.

DOI:10.14202/vetworld.2024.407-412
PMID:38595656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11000480/
Abstract

BACKGROUND AND AIM

is responsible for brucellosis, a highly contagious, life-threatening disease that has a high impact in low- and middle-income countries. This study aimed to compare silica nanoparticles (SiO-NPs) loaded with ciprofloxacin with silver nanoparticles (AgNPs) loaded with ciprofloxacin to evaluate the possible replacement of silver by silica to enhance biological activity and reduce cytotoxicity.

MATERIALS AND METHODS

SiO-NPs and AgNPs loaded with ciprofloxacin were characterized using ultraviolet spectroscopy, scanning electron microscopy, and dynamic light scattering microscopy for size demonstration and loading efficiency. Both nanoparticles were treated with Rev 1 to evaluate their biological activity. Nanoparticle toxicity was also evaluated using cytotoxicity and hemolysis assays.

RESULTS

SiO-NP was found to have a smaller size (80 nm) and higher loading efficiency with polydispersity index and zeta potential of 0.43 and 30.7 mV, respectively, compared to Ag-NP (180 nm and 0.62 and 28.3 mV, respectively). SiO-NP was potent with a minimum inhibitory concentration of 0.043 μg/mL compared to Ag-NP (0.049 μg/mL), with a lower cytotoxicity and hemolysis activity.

CONCLUSION

SiO-NP, as a drug delivery system for ciprofloxacin, has better antimicrobial activity against with lower cytotoxicity and hemolysis activity. These results can be attributed to the enhanced physical characterization and better loading efficiency when compared to Ag-NP.

摘要

背景与目的

布鲁氏菌病具有高度传染性，会危及生命，在低收入和中等收入国家影响重大。本研究旨在比较负载环丙沙星的二氧化硅纳米颗粒（SiO-NPs）和负载环丙沙星的银纳米颗粒（AgNPs），以评估用二氧化硅替代银是否有可能增强生物活性并降低细胞毒性。

材料与方法

采用紫外光谱、扫描电子显微镜和动态光散射显微镜对负载环丙沙星的SiO-NPs和AgNPs进行表征，以展示其尺寸和负载效率。两种纳米颗粒均用Rev 1处理以评估其生物活性。还使用细胞毒性和溶血试验评估纳米颗粒的毒性。

结果

发现SiO-NP尺寸较小（80纳米），负载效率更高，其多分散指数和zeta电位分别为0.43和30.7毫伏，而Ag-NP分别为180纳米、0.62和28.3毫伏。与Ag-NP（最低抑菌浓度为0.049微克/毫升）相比，SiO-NP效力更强，最低抑菌浓度为0.043微克/毫升，且细胞毒性和溶血活性更低。

结论

SiO-NP作为环丙沙星的药物递送系统，对[此处原文缺失具体病菌名称]具有更好的抗菌活性，细胞毒性和溶血活性更低。与Ag-NP相比，这些结果可归因于其增强的物理特性和更好的负载效率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/11000480/75ed8133b028/Vetworld-17-407-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/11000480/5c5cf3b7bde9/Vetworld-17-407-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/11000480/861e5f8b31b5/Vetworld-17-407-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/11000480/fcfb42a779be/Vetworld-17-407-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/11000480/75ed8133b028/Vetworld-17-407-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/11000480/5c5cf3b7bde9/Vetworld-17-407-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/11000480/861e5f8b31b5/Vetworld-17-407-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/11000480/fcfb42a779be/Vetworld-17-407-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6338/11000480/75ed8133b028/Vetworld-17-407-g004.jpg

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