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血浆 C1q/肿瘤坏死因子相关蛋白 3（CTRP3）与心房颤动患者的相关性。

Association of Plasma C1q/TNF-Related Protein 3 (CTRP3) in Patients with Atrial Fibrillation.

机构信息

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, 49 Huayuan-Bei Road, Haidian District, Beijing 100191, China.

Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, 49 Huayuan-Bei Road, Haidian District, Beijing 100191, China.

出版信息

Mediators Inflamm. 2020 Dec 24;2020:8873152. doi: 10.1155/2020/8873152. eCollection 2020.

DOI:10.1155/2020/8873152
PMID:33424438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7781729/
Abstract

Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia characterized by atrial remodeling. Complement C1q tumor necrosis factor-related protein 3 (CTRP3) is one of the adipokines associated with obesity, diabetes, and coronary heart disease. The association between plasma CTRP3 levels and AF is uncertain. The aim of this study was to investigate whether plasma CTRP3 concentrations were correlated with AF. Our study included 75 AF patients who underwent catheter ablation at our hospital and 47 sinus rhythm patients to determine the difference in plasma CTRP3 concentrations. Blood samples before the ablation were collected, and ELISA was used to measure the concentrations of CTRP3. Plasma CTRP3 concentrations were significantly lower in AF patients compared with control group (366.9 ± 105.2 ng/ml vs. 429.1 ± 100.1 ng/ml, = 0.002). In subgroup studies, patients with persistent AF had lower plasma CTRP3 concentrations than those with paroxysmal AF (328.3 ± 83.3 ng/ml vs. 380.0 ± 109.2 ng/ml, = 0.037). The concentrations of plasma CTRP3 in the recurrence group after radiofrequency catheter ablation of AF were lower than those in the nonrecurrence group (337.9 ± 77.3 ng/ml vs. 386.6 ± 108.1 ng/ml, = 0.045). Multivariate regression analysis revealed the independent correlation between plasma CTRP3 level and AF. Plasma CTRP3 concentrations were correlated with the presence of AF and AF recurrence.

摘要

心房颤动（AF）是一种以心房重构为特征的高发心律失常。补体 C1q 肿瘤坏死因子相关蛋白 3（CTRP3）是与肥胖、糖尿病和冠心病相关的脂肪因子之一。血浆 CTRP3 水平与 AF 的关系尚不确定。本研究旨在探讨血浆 CTRP3 浓度与 AF 是否相关。我们的研究纳入了 75 名在我院接受导管消融的 AF 患者和 47 名窦性心律患者，以确定血浆 CTRP3 浓度的差异。在消融前采集血样，并使用 ELISA 测定 CTRP3 浓度。AF 患者的血浆 CTRP3 浓度明显低于对照组（366.9±105.2ng/ml 比 429.1±100.1ng/ml， = 0.002）。在亚组研究中，持续性 AF 患者的血浆 CTRP3 浓度低于阵发性 AF 患者（328.3±83.3ng/ml 比 380.0±109.2ng/ml， = 0.037）。AF 射频导管消融后复发组的血浆 CTRP3 浓度低于未复发组（337.9±77.3ng/ml 比 386.6±108.1ng/ml， = 0.045）。多变量回归分析显示，血浆 CTRP3 水平与 AF 之间存在独立相关性。血浆 CTRP3 浓度与 AF 的存在和复发相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/626b/7781729/c8565c471f7a/MI2020-8873152.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/626b/7781729/c68bed8ea7df/MI2020-8873152.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/626b/7781729/f489fecfaa50/MI2020-8873152.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/626b/7781729/c8565c471f7a/MI2020-8873152.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/626b/7781729/c68bed8ea7df/MI2020-8873152.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/626b/7781729/f489fecfaa50/MI2020-8873152.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/626b/7781729/c8565c471f7a/MI2020-8873152.003.jpg

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