Deng Wuquan, Li Changyan, Zhang Yuping, Zhao Jie, Yang Mengliu, Tian Mingyuan, Li Ling, Zheng Yanling, Chen Bing, Yang Gangyi
Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010 China.
Department of Nephropathy, Chengdu Fifth Pepole's Hospital, Sichuan Province, 611130 China.
Diabetol Metab Syndr. 2015 Apr 10;7:33. doi: 10.1186/s13098-015-0029-0. eCollection 2015.
Insulin resistance (IR) correlates closely with cardiovascular disease. C1q/TNF-related protein-3 (CTRP3) is a novel adipokine that modulates insulin activity in various diseases. This study investigated the relationship between CTRP3 and IR as well as systemic inflammation in newly diagnosed obese and hypertensive patients (NCT02226471).
Serum CTRP3 levels, anthropometric, inflammatory and metabolic parameters were measured in 180 obesity and essential hypertensive patients and in 66 normal weight, normotensive subjects.
The serum CTRP3 levels in the obesity group were lower than those in the NW group; these levels were also lower in hypertensive subjects than in normotensive subjects. After adjusting for gender, systolic blood pressure (SBP) and diastolic blood pressure (DBP), a modestly linear relationship was observed between CTRP3 and waist circumference (WC) (r = -0.168, p = 0.009), waist-to-hip ratio (WHR) (r = -0.183, p = 0.004), homeostasis model assessment of IR (HOMA-IR) (r = -0.264, p = 0.000), triglycerides (TG) (r = -0.136, p = 0.034), fasting blood glucose (FBG) (r = -0.155, p = 0.016), fasting insulin (FINS) (r = -0.248, p = 0.000) and homeostasis model assessment of β-cell insulin secretion (HOMA-β) (r = -0.128, p = 0.047). Multiple stepwise regression analysis revealed that gender, DBP and HOMA-IR were independently associated with serum CTRP3 levels.
CTRP3 was an independent factor affecting blood pressure and IR, and may play an important role in the pathogenesis of obesity and hypertension.
胰岛素抵抗（IR）与心血管疾病密切相关。C1q/TNF相关蛋白3（CTRP3）是一种新型脂肪因子，可在多种疾病中调节胰岛素活性。本研究调查了新诊断的肥胖和高血压患者中CTRP3与IR以及全身炎症之间的关系（NCT02226471）。
对180例肥胖和原发性高血压患者以及66例体重正常、血压正常的受试者测量血清CTRP3水平、人体测量学、炎症和代谢参数。
肥胖组血清CTRP3水平低于正常体重组；高血压受试者的这些水平也低于血压正常的受试者。在调整性别、收缩压（SBP）和舒张压（DBP）后，观察到CTRP3与腰围（WC）（r = -0.168，p = 0.009）、腰臀比（WHR）（r = -0.183，p = 0.004）、IR的稳态模型评估（HOMA-IR）（r = -0.264，p = 0.000）、甘油三酯（TG）（r = -0.136，p = 0.034）、空腹血糖（FBG）（r = -0.155，p = 0.016）、空腹胰岛素（FINS）（r = -0.248，p = 0.000）和β细胞胰岛素分泌的稳态模型评估（HOMA-β）（r = -0.128，p = 0.047）之间存在适度的线性关系。多元逐步回归分析显示，性别、DBP和HOMA-IR与血清CTRP3水平独立相关。
CTRP3是影响血压和IR的独立因素，可能在肥胖和高血压的发病机制中起重要作用。
