Du Yang, Jiang Shukun, Cheng Longlong, Liu Jihui
The 7th People's Hospital of Shenyang Shenyang, Liaoning Province, P. R. China.
Department of Forensic Clinical Medicine, School of Forensic Medicine, China Medical University Shenyang, Liaoning Province, P. R. China.
Int J Clin Exp Pathol. 2020 Dec 1;13(12):3111-3119. eCollection 2020.
Psoriasis is reportedly modulated by the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) or vascular endothelial growth factor/p21-activated kinase 1 (VEGF/PAK1) pathways. However, no research has evaluated the expression of JAK/STAT and VEGF/PAK1 signaling pathway molecules in human psoriasis skin tissue concurrently. We investigated the expression of autocrine STAT1, STAT3, VEGF, suppressor of cytokine signaling-1 (SOCS1), SOCS3, and PAK1 in psoriatic tissues. Skin biopsies were retrospectively collected from 55 patients with psoriasis from the tissue biobank. Skin biopsies from 40 healthy volunteers undergoing plastic surgery were used as controls. Immunohistochemical staining revealed that STAT1, STAT3, SOCS1, SOCS3, VEGF, and PAK1 were present at significantly higher levels in the psoriasis samples compared to the control group. Similarly, the mRNA expression of these signaling molecules was also significantly upregulated in psoriatic skin. Additionally, some of the molecules in these two signaling pathways exhibited significant positive correlations. In summary, we present pilot evidence that JAK/STAT and VEGF/PAK1 signaling molecules are expressed in psoriasis, which may provide topical treatment targets for this disease.
据报道，银屑病受Janus激酶（JAK）/信号转导子和转录激活子（STAT）或血管内皮生长因子/p21激活激酶1（VEGF/PAK1）信号通路调控。然而，尚无研究同时评估JAK/STAT和VEGF/PAK1信号通路分子在人银屑病皮肤组织中的表达情况。我们研究了自分泌信号分子STAT1、STAT3、VEGF、细胞因子信号抑制因子1（SOCS1）、SOCS3和PAK1在银屑病组织中的表达。回顾性收集了组织生物样本库中55例银屑病患者的皮肤活检样本。选取40例接受整形手术的健康志愿者的皮肤活检样本作为对照。免疫组化染色显示，与对照组相比，银屑病样本中STAT1、STAT3、SOCS1、SOCS3、VEGF和PAK1的表达水平显著更高。同样，这些信号分子的mRNA表达在银屑病皮肤中也显著上调。此外，这两条信号通路中的一些分子呈现出显著的正相关。总之，我们提供的初步证据表明，JAK/STAT和VEGF/PAK1信号分子在银屑病中表达，这可能为该病提供局部治疗靶点。
