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经皮经肝胆道支架置入术在恶性梗阻性黄疸姑息治疗中的应用:加纳一家三级中心的初步经验。

Percutaneous transhepatic biliary stent placement in the palliative management of malignant obstructive jaundice: initial experience in a tertiary center in Ghana.

机构信息

Department of Radiology, School of Medicine and Dentistry, University of Ghana, Accra, Ghana.

Department of Radiography, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana.

出版信息

Pan Afr Med J. 2020 Sep 27;37:96. doi: 10.11604/pamj.2020.37.96.20050. eCollection 2020.

Abstract

INTRODUCTION

one of the mainstays of management of malignant biliary obstruction is the decompression of the biliary system and its associated obstructive symptoms. Non-surgical palliative treatment such as percutaneous transhepatic biliary stenting is desirable in many selected patients. However, this service is often not available in many resource-limited countries. We share our initial experience of percutaneous transhepatic biliary stenting for the management of malignant biliary obstruction in our first set of patients with surgically non resectable malignant biliary obstruction in Ghana.

METHODS

percutaneous transhepatic biliary stenting was performed on the first 23 consecutive patients at the Korle Bu Teaching Hospital. The procedure served as the first palliation for malignant obstruction through interventional radiology. Medical records as well as serum levels of total bilirubin (TBil), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were used to assess the efficiency of the intervention. Microsoft Excel 2010 was used to analysis the data.

RESULTS

most patients had resolution of jaundice with marked improvement in liver function and resolution of the itching associated with obstructive jaundice. During the follow-up of cases, one major complication of hemoperitoneum occurred requiring laparotomy. No other major complications such as bile leakage or death occurred. Four (4) patients had sepsis, which was managed.

CONCLUSION

the introduction of the intervention in Ghana has proven to valuable for palliative drainage and relief of obstructive symptoms, hence contributing to better patient management. It is relatively safe with minor complications among Ghanaians with non-resectable obstructive symptoms.

摘要

介绍

恶性胆道梗阻管理的主要方法之一是胆道系统减压及其相关的阻塞症状。在许多选定的患者中,经皮经肝胆道支架置入术等非手术姑息治疗是理想的选择。然而,在许多资源有限的国家,这种服务往往无法提供。我们分享了在加纳,我们对第一组无法手术切除的恶性胆道梗阻患者进行经皮经肝胆道支架置入术治疗恶性胆道梗阻的初步经验。

方法

在 Korle Bu 教学医院对前 23 名连续患者进行了经皮经肝胆道支架置入术。该程序通过介入放射学作为恶性梗阻的第一次姑息治疗。使用病历以及总胆红素 (TBil)、天门冬氨酸氨基转移酶 (AST)、丙氨酸氨基转移酶 (ALT) 和碱性磷酸酶 (ALP) 的血清水平来评估干预的效率。使用 Microsoft Excel 2010 分析数据。

结果

大多数患者的黄疸消退,肝功能明显改善,与阻塞性黄疸相关的瘙痒也得到缓解。在对病例进行随访期间,发生了一例严重的并发症——血腹,需要剖腹手术。没有发生其他主要并发症,如胆汁漏或死亡。有 4 名(4 名)患者发生了感染,经治疗后得到了控制。

结论

该介入技术在加纳的引入已被证明对姑息性引流和缓解阻塞症状非常有价值,从而有助于更好地管理患者。对于加纳患有不可切除的阻塞症状的患者来说,它相对安全,并发症较少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d788/7757328/e1438cc29388/PAMJ-37-96-g001.jpg

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