Priya Gagan, Kalra Sanjay, Dasgupta Arundhati, Grewal Emmy
Endocrinology, Fortis Hospital, Mohali, IND.
Endocrinology, Bharti Research Institute of Diabetes and Endocrinology (BRIDE), Karnal, IND.
Cureus. 2021 Jan 5;13(1):e12498. doi: 10.7759/cureus.12498.
Diabetes insipidus (DI) is a disorder of water balance characterized by polyuria and polydipsia. It can occur due to genetic and acquired causes that affect the secretion or action of arginine vasopressin (AVP) or antidiuretic hormone (ADH).Markedly increased thirst and urination are not only quite distressing but also increases the risk of volume depletion and hypernatremia in severe situations. A careful diagnosis of the type of DI and its etiology is based on careful clinical evaluation, measurement of urine and serum osmolality, and water deprivation test. Management includes the correction of any water deficit and the use of specific pharmacological agents, including desmopressin, thiazides, and amiloride.
尿崩症（DI）是一种水平衡紊乱疾病，其特征为多尿和烦渴。它可由影响精氨酸加压素（AVP）或抗利尿激素（ADH）分泌或作用的遗传及后天因素引起。明显增加的口渴感和尿量不仅令人极为苦恼，在严重情况下还会增加容量耗竭和高钠血症的风险。对尿崩症类型及其病因的准确诊断基于细致的临床评估、尿和血清渗透压的测量以及禁水试验。治疗包括纠正任何水分缺失以及使用特定的药物制剂，包括去氨加压素、噻嗪类药物和氨氯吡咪。
