Department of Molecular and Cell Biology, School of Natural Sciences, University of California-Merced, Merced, CA, United States.
Quantitative and Systems Biology Graduate Program, University of California-Merced, Merced, CA, United States.
Front Cell Infect Microbiol. 2020 Dec 3;10:605711. doi: 10.3389/fcimb.2020.605711. eCollection 2020.
is a commensal member of the human microbiota that colonizes multiple niches in the body including the skin, oral cavity, and gastrointestinal and genitourinary tracts of healthy individuals. It is also the most common human fungal pathogen isolated from patients in clinical settings. can cause a number of superficial and invasive infections, especially in immunocompromised individuals. The ability of to succeed as both a commensal and a pathogen, and to thrive in a wide range of environmental niches within the host, requires sophisticated transcriptional regulatory programs that can integrate and respond to host specific environmental signals. Identifying and characterizing the transcriptional regulatory networks that control important developmental processes in will shed new light on the strategies used by to colonize and infect its host. Here, we discuss the transcriptional regulatory circuits controlling three major developmental processes in : biofilm formation, the white-opaque phenotypic switch, and the commensal-pathogen transition. Each of these three circuits are tightly knit and, through our analyses, we show that they are integrated together by extensive regulatory crosstalk between the core regulators that comprise each circuit.
是人体微生物群的共生成员，定植于人体多个生态位，包括皮肤、口腔、胃肠道和泌尿生殖道。它也是从临床环境中患者身上分离出来的最常见的人类真菌病原体。可以引起许多浅表和侵袭性感染，尤其是在免疫功能低下的个体中。能够成功地作为共生菌和病原体存在，并在宿主内的广泛环境生态位中茁壮成长，需要复杂的转录调控程序，这些程序可以整合并响应宿主特定的环境信号。鉴定和描述控制 中重要发育过程的转录调控网络，将为 定植和感染宿主所使用的策略提供新的认识。在这里，我们讨论了控制 中三个主要发育过程的转录调控回路：生物膜形成、白-暗表型转换和共生-病原体转换。这三个回路中的每一个都紧密相连，通过我们的分析，我们表明它们通过构成每个回路的核心调节剂之间的广泛调控串扰整合在一起。
