Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.
Mycotoxin Res. 2021 Feb;37(1):109-116. doi: 10.1007/s12550-020-00421-9. Epub 2021 Jan 11.
Aflatoxin (AF) contamination of food products is still a major health issue globally. Prior studies suggest that exposure to AFs during pregnancy has harmful fetal outcomes. This preliminary study was designed to assess serum AFB levels in neonatal jaundice (NNJ) secondary to glucose-6-phosphate dehydrogenase (G6PD) deficiency. Twenty-four full-term neonates with hemolytic jaundice secondary to G6PD deficiency were enrolled in the study. Erythrocyte G6PD status was assessed colorimetrically, and serum aflatoxin B (AFB) concentrations were measured by high-performance liquid chromatography. The results revealed that AFB was detected in 58% (14/24) of the studied newborns while detected in 75% (18/24) of their mothers. AFB positive cases had a highly significantly lower birthweight and G6PD activity (P = 0.001, each). Birthweight (r = - 0.574, P = 0.032) and G6PD activity (r = - 0.585, P = 0.028) negatively correlated with serum AFB levels while serum alanine aminotransferase activity positively correlated with serum AFB levels (r = 0.536, P = 0.048). Maternal AFB exposure is associated with adverse birth outcomes as verified by the low birthweight and the evident decline in the activity of G6PD enzyme with the resultant hemolytic NNJ.
食品中黄曲霉毒素（AF）的污染仍然是一个全球性的主要健康问题。先前的研究表明，孕妇接触 AF 会对胎儿产生有害影响。本初步研究旨在评估葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症引起的新生儿黄疸（NNJ）中血清 AFB 水平。本研究纳入了 24 例因 G6PD 缺乏症引起溶血性黄疸的足月新生儿。通过比色法评估红细胞 G6PD 状态，并通过高效液相色谱法测量血清黄曲霉毒素 B（AFB）浓度。结果显示，在研究的新生儿中，有 58%（14/24）检测到 AFB，而在其母亲中，有 75%（18/24）检测到 AFB。AFB 阳性病例的出生体重和 G6PD 活性显著降低（P=0.001，各）。出生体重（r=-0.574，P=0.032）和 G6PD 活性（r=-0.585，P=0.028）与血清 AFB 水平呈负相关，而血清丙氨酸氨基转移酶活性与血清 AFB 水平呈正相关（r=0.536，P=0.048）。母体 AFB 暴露与不良出生结局有关，这可以通过低出生体重和 G6PD 酶活性明显下降导致的溶血性 NNJ 来证实。
