Sletvold O, Laerum O D, Riise T
Gade Institute, Department of Pathology, University of Bergen, Haukeland Hospital, Norway.
Eur J Haematol. 1988 Jan;40(1):42-9. doi: 10.1111/j.1600-0609.1988.tb00795.x.
The effect of aging on the myelopoietic progenitor cell (CFU-GM) numbers in mice was studied with special emphasis on biological rhythms in hemopoiesis. Female C3H mice, 16-, 21- and 26-month-old, were investigated versus 3-month-old controls every 3 hours during the 24-h period at three different times of the year. Strong circadian rhythms were observed in both CFU-GM concentration and content in the femur of all age-groups. The amplitudes and the 24-h mean values were declining in mice aged 21 and 26 months. From 16 months of age, a significant advance of circadian peak phases was observed. The overlapping was variable during the 24-h period. The present results may explain previous inconsistencies regarding myelopoietic progenitor cell numbers in aging mice. Some seasonal differences in rhythmicity patterns were also observed. Fitting of original data to single sinus functions was highly significant, although important details sometimes were obscured.
研究了衰老对小鼠骨髓造血祖细胞（CFU-GM）数量的影响，特别关注造血过程中的生物节律。在一年中的三个不同时间，对16、21和26月龄的雌性C3H小鼠与3月龄的对照小鼠在24小时内每3小时进行一次研究。在所有年龄组的股骨中，CFU-GM浓度和含量均观察到强烈的昼夜节律。21和26月龄小鼠的振幅和24小时平均值均下降。从16月龄开始，观察到昼夜峰值相位明显提前。在24小时期间重叠情况各不相同。目前的结果可能解释了先前关于衰老小鼠骨髓造血祖细胞数量的不一致之处。还观察到节律模式存在一些季节性差异。将原始数据拟合为单正弦函数非常显著，尽管有时重要细节会被掩盖。
