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三元复合物中双链DNA的互补定向修饰

Complementary addressed modification of double-stranded DNA within a ternary complex.

作者信息

Fedorova O S, Knorre D G, Podust L M, Zarytova V F

机构信息

Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk.

出版信息

FEBS Lett. 1988 Feb 15;228(2):273-6. doi: 10.1016/0014-5793(88)80014-0.

DOI:10.1016/0014-5793(88)80014-0
PMID:3342881
Abstract

Double-stranded DNA containing a d(pG)18.d(pC)18 sequence was shown to be selectively alkylated in the vicinity of this fragment using the 5'-p-(N-2-chloroethyl-N-methylamino)benzylamide of deoxyribooligocytidylate, CIRCH2NH(pdC)n (n = 9,15), in conditions favouring triple-stranded complex formation.

摘要

在有利于三链复合物形成的条件下，使用脱氧核糖寡聚胞苷酸的5'-p-(N-2-氯乙基-N-甲基氨基)苄酰胺，即CIRCH2NH(pdC)n（n = 9,15），已证明含有d(pG)18.d(pC)18序列的双链DNA在该片段附近被选择性烷基化。

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Complementary addressed modification of double-stranded DNA within a ternary complex.三元复合物中双链DNA的互补定向修饰
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Effect of abasic linker substitution on triplex formation, Sp1 binding, and specificity in an oligonucleotide targeted to the human Ha-ras promoter.
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Nucleic Acids Res. 1994 May 25;22(10):1909-16. doi: 10.1093/nar/22.10.1909.
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Sequence-specific recognition and cleavage of duplex DNA via triple-helix formation by oligonucleotides covalently linked to a phenanthroline-copper chelate.通过与菲咯啉 - 铜螯合物共价连接的寡核苷酸形成三链螺旋对双链DNA进行序列特异性识别和切割。
Proc Natl Acad Sci U S A. 1989 Dec;86(24):9702-6. doi: 10.1073/pnas.86.24.9702.
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