Tanaka Naonobu, Takahashi Sakura, Kajihara Seita, Tsuji Daisuke, Itoh Kohji, Mamadalieva Nilufar Z, Kashiwada Yoshiki
Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan.
Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent 100170, Uzbekistan.
Fitoterapia. 2021 Mar;149:104826. doi: 10.1016/j.fitote.2021.104826. Epub 2021 Jan 8.
Phytochemical investigation on the aerial parts of a Lamiaceous medicinal plant Perovskia scrophulariifolia collected in Uzbekistan resulted in the isolation of two new 20-norabietane diterpenes, along with thirteen known diterpenes including one 20-norabietane, eight abietanes, one 6,7-secoabietane, and three icetexanes. The structures of new 20-norabietane diterpenes, perovsfolins C (1) and D (2), were elucidated by spectroscopic analyses aided with calculations of ECD spectra. Perovsfolin C (1) is the first 20-norabietane diterpene possessing a 1,11-epoxy moiety, while perovsfolin D (2) is a 20-norabitetane diterpene with a 2-hydroxy-1,4-quinone moiety as C-ring. Anti-neuroinflammatory activity of the isolated diterpenes on microglial cells was evaluated.
对采自乌兹别克斯坦的唇形科药用植物紫花糙苏地上部分进行植物化学研究，结果分离出两种新的20 - 降松香烷二萜，以及13种已知二萜，包括一种20 - 降松香烷、8种枞烷、一种6,7 - 裂枞烷和3种紫杉叶烷。通过光谱分析并辅助电子圆二色光谱（ECD）计算，阐明了新的20 - 降松香烷二萜紫苏叶素C（1）和紫苏叶素D（2）的结构。紫苏叶素C（1）是首个具有1,11 - 环氧部分的20 - 降松香烷二萜，而紫苏叶素D（2）是一种C环带有2 - 羟基 - 1,4 - 醌部分的20 - 降松香烷二萜。评估了分离得到的二萜对小胶质细胞的抗神经炎症活性。
