Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, 1983969411 Tehran, Iran.
Dipartimento di Farmacia, Università degli Studi di Salerno, via Giovanni Paolo II n. 132, 84084 Fisciano (SA), Italy.
J Nat Prod. 2021 Apr 23;84(4):1185-1197. doi: 10.1021/acs.jnatprod.0c01256. Epub 2021 Mar 22.
Fractionation of an EtOAc extract of the roots of yielded 28 diterpenoids, including 12 new analogues, -. The structures of these diterpenoids were established using comprehensive spectroscopic data analysis, including 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism spectroscopy, and comparison with literature data. The extract and some of the tested compounds showed significant anti-inflammatory activity on J774A.1 macrophage cells stimulated with . lipopolysaccharide. In particular, the tested compounds significantly inhibited the release of nitric oxide and the expression of related proinflammatory enzymes, such as inducible nitric oxide synthase.
从 的根部分离出的 EtOAc 提取物得到了 28 种二萜类化合物，包括 12 种新类似物， - 。这些二萜类化合物的结构是通过综合光谱数据分析确定的，包括 1D 和 2D NMR、高分辨率电喷雾电离质谱、电子圆二色光谱以及与文献数据的比较。提取物和一些测试化合物对 J774A.1 巨噬细胞显示出显著的抗炎活性，这些细胞受到 脂多糖刺激。特别是，测试化合物显著抑制了一氧化氮的释放和相关促炎酶的表达，如诱导型一氧化氮合酶。
