Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, People's Republic of China.
Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan 750004, People's Republic of China.
Nanotechnology. 2021 Apr 16;32(16):165703. doi: 10.1088/1361-6528/abda74.
Chemotherapy is one of conventional treatment methods for breast cancer, but drug toxicity and side effects have severely limited its clinical applications. Photothermal therapy has emerged as a promising method that, upon combination with chemotherapy, can better treat breast cancer. In this context, a biodegradable mesoporous silica nanoparticle (bMSN NPs) system was developed for loading doxorubicin (DOX) and IR780, to be potentially applied in the treatment of breast cancer. IR780 is encapsulated in the pores of bMSN NPs by hydrophobic adsorption, while DOX is adsorbed on the surface of the bMSN NPs by hyaluronic acid electrostatically, to form the bMID NPs. Transmission electron microscopy, fluorescence spectrum and UV absorption spectrum are used to prove the successful encapsulation of IR780 and the loading of DOX. In vitro experiments have shown bMID NPs present an excellent therapeutic effect on breast cancer cells. In vivo fluorescence imaging results have indicated that bMID NPs can accumulate in tumor sites gradually and achieve in vivo long-term circulation and continuous drug release. Furthermore, bMID NPs have provided obvious antitumor effects in breast cancer mouse models, thus evolving as an efficient platform for breast cancer therapy.
化疗是乳腺癌的常规治疗方法之一，但药物毒性和副作用严重限制了其临床应用。光热疗法作为一种很有前途的方法，与化疗结合使用，可以更好地治疗乳腺癌。在这种情况下，开发了一种可生物降解的介孔硅纳米粒子（bMSN NPs）系统，用于装载阿霉素（DOX）和 IR780，以潜在应用于乳腺癌的治疗。IR780 通过疏水吸附被包裹在 bMSN NPs 的孔中，而 DOX 通过透明质酸静电吸附在 bMSN NPs 的表面上，形成 bMID NPs。透射电子显微镜、荧光光谱和紫外吸收光谱用于证明 IR780 的成功封装和 DOX 的负载。体外实验表明 bMID NPs 对乳腺癌细胞具有优异的治疗效果。体内荧光成像结果表明，bMID NPs 可以逐渐在肿瘤部位聚集，并实现体内的长期循环和持续药物释放。此外，bMID NPs 在乳腺癌小鼠模型中表现出明显的抗肿瘤作用，因此成为一种有效的乳腺癌治疗平台。
