Chu Xiao, Li Kang, Guo Hongyu, Zheng Huibin, Shuda Suzanne, Wang Xiaolan, Zhang Junying, Chen Wei, Zhang Yu
Guangdong Key Lab of Orthopaedic Technology and Implant Materials, Key Laboratory of Trauma & Tissue Repair of Tropical Area of PLA, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China.
Key Laboratory of Micro-nano Measurement, Manipulation and Physics (Ministry of Education), Department of Physics, Beihang University, Beijing 100191, China.
ACS Biomater Sci Eng. 2017 Aug 14;3(8):1836-1844. doi: 10.1021/acsbiomaterials.7b00110. Epub 2017 Jun 15.
Here, we report our new observations on graphitic-phase carbon nitride (g-CN) quantum dots (QDs) as agents for microwave induced photodynamic therapy (MIPDT). For the first time, we observed that singlet oxygen is produced in g-CN QDs by microwave irradiation, which can be used for tumor destruction. The results of live/dead staining and flow cytometry show that g-CN QDs based MIPDT can effectively kill cancer cells and promote tumor cell death. In addition, the cell viability and hemolysis tests in vitro indicate that g-CN QDs have very low cell toxicity and possess excellent biocompatibility in the physiological environments. All these indicate that g-CN QDs are promising for MIPDT, a new potential modality for cancer treatment.
在此，我们报告了关于石墨相氮化碳（g-CN）量子点（QDs）作为微波诱导光动力疗法（MIPDT）试剂的新观察结果。我们首次观察到，微波辐照可使g-CN量子点产生单线态氧，其可用于肿瘤破坏。活/死染色和流式细胞术结果表明，基于g-CN量子点的MIPDT可有效杀死癌细胞并促进肿瘤细胞死亡。此外，体外细胞活力和溶血试验表明，g-CN量子点具有非常低的细胞毒性，并且在生理环境中具有优异的生物相容性。所有这些表明，g-CN量子点在MIPDT方面具有前景，MIPDT是一种新的癌症治疗潜在模式。
