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关于柱孢藻毒素毒性的新数据。

New Data on Cylindrospermopsin Toxicity.

机构信息

Department of Animal and Human Physiology, Faculty of Biology, Sofia University "St. Kliment Ohridski", 8 Dragan Tzankov blvd., 1164 Sofia, Bulgaria.

Department of Biochemistry, Molecular Medicine and Nutrigenomics, Faculty of Pharmacy, Medical University of Varna, 55 Marin Drinov, 9002 Varna, Bulgaria.

出版信息

Toxins (Basel). 2021 Jan 8;13(1):41. doi: 10.3390/toxins13010041.

DOI:10.3390/toxins13010041
PMID:33429940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7827247/
Abstract

Cylindrospermopsin (CYN) is a widely spread cyanotoxin that can occur in fresh water and food. This research aims to investigate CYN toxicity by studying the effects of drinking 0.25 nM of CYN-contaminated water from a natural source, and of the direct application of moderate concentrations of CYN on different animal targets. The chosen structures and activities are rat mitochondria inner membrane permeability, mitochondrial ATP synthase (ATPase) and rat liver diamine oxidase (DAO) activities (EC 1.4.3.22.), the force of the contraction of an excised frog heart preparation with functional innervation, and the viability of a human intestinal epithelial cell line (HIEC-6). The oral exposure to CYN decreased the reverse (hydrolase) activity of rat liver ATPase whereas its short-term, in vitro application was without significant effect on this organelle, DAO activity, heart contractions, and their neuronal regulation. The application of CYN reduced HIEC-6 cells' viability dose dependently. It was concluded that CYN is moderately toxic for the human intestinal epithelial cells, where the regeneration of the epithelial layer can be suppressed by CYN. This result suggests that CYN may provoke pathological changes in the human gastrointestinal tract.

摘要

柱孢藻毒素（CYN）是一种广泛分布的蓝藻毒素，存在于淡水和食物中。本研究旨在通过研究饮用天然水源中 0.25nM 污染的 CYN 水，以及直接应用中等浓度的 CYN 对不同动物靶标的影响，来研究 CYN 的毒性。选择的结构和活性包括大鼠线粒体内膜通透性、线粒体 ATP 合酶（ATPase）和大鼠肝二胺氧化酶（DAO）活性（EC 1.4.3.22）、具有功能神经支配的离体蛙心标本的收缩力以及人肠上皮细胞系（HIEC-6）的活力。口服暴露于 CYN 会降低大鼠肝 ATPase 的逆（水解酶）活性，而其短期的体外应用对该细胞器、DAO 活性、心脏收缩及其神经元调节没有显著影响。CYN 的应用剂量依赖性地降低了 HIEC-6 细胞的活力。研究得出结论，CYN 对人肠上皮细胞具有中等毒性，可抑制上皮层的再生。这一结果表明，CYN 可能会引起人体胃肠道的病理变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0848/7827247/ebc07748689c/toxins-13-00041-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0848/7827247/c2fd1b1526d1/toxins-13-00041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0848/7827247/4509c8643311/toxins-13-00041-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0848/7827247/bd5a5e27122a/toxins-13-00041-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0848/7827247/b34e7348f92e/toxins-13-00041-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0848/7827247/ebc07748689c/toxins-13-00041-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0848/7827247/c2fd1b1526d1/toxins-13-00041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0848/7827247/4509c8643311/toxins-13-00041-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0848/7827247/bd5a5e27122a/toxins-13-00041-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0848/7827247/b34e7348f92e/toxins-13-00041-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0848/7827247/ebc07748689c/toxins-13-00041-g005.jpg

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Global scanning of cylindrospermopsin: Critical review and analysis of aquatic occurrence, bioaccumulation, toxicity and health hazards.全球范围内对柱孢藻毒素的扫描：水生环境中分布、生物蓄积、毒性和健康危害的分析与评估。
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Cylindrospermopsin-Microcystin-LR Combinations May Induce Genotoxic and Histopathological Damage in Rats.
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Toxins (Basel). 2022 Nov 11;14(11):785. doi: 10.3390/toxins14110785.
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