Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
The Miami Project to Cure Paralysis, Peggy and Harold Katz Family Drug Discovery Center, Sylvester Comprehensive Cancer Center, and Departments of Neurological Surgery and Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Int J Mol Sci. 2021 Jan 8;22(2):566. doi: 10.3390/ijms22020566.
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.
我们描述了一组化学基因组蛋白激酶抑制剂的组装和注释，将其作为研究激酶生物学的开放科学资源。该集合仅包括在大型激酶生化测定面板中筛选时显示出强大的激酶抑制作用和窄谱活性的抑制剂。目前，该集合包含 187 种抑制剂，涵盖 215 种人类激酶。激酶化学基因组集合（KCGS），当前版本 1.0，是研究人员在基于细胞的筛选中可使用的最具注释的选择性激酶抑制剂集合。
