Reichstein Wiebke, Sommer Levke, Veziroglu Salih, Sayin Selin, Schröder Stefan, Mishra Yogendra Kumar, Saygili Eyüp İlker, Karayürek Fatih, Açil Yahya, Wiltfang Jörg, Gülses Aydin, Faupel Franz, Aktas Oral Cenk
Chair for Multicomponent Materials, Institute of Materials Science, Faculty of Engineering, Kiel University, Kaiserstr. 2, 24143 Kiel, Germany.
Department of Oral and Maxillofacial Surgery, Campus Kiel, University Hospital of Schleswig-Holstein, Arnold-Heller-Straße 3, 24105 Kiel, Germany.
Polymers (Basel). 2021 Jan 7;13(2):186. doi: 10.3390/polym13020186.
The current study aimed to describe the fabrication of a composite patch by incorporating marine algae powders (MAPs) into poly-lactic acid (PLA) for bone tissue engineering. The prepared composite patch was functionalized with the co-polymer, poly (2-hydroxyethyl methacrylate-co-ethylene glycol dimethacrylate) (p(HEMA-co-EGDMA)) via initiated chemical vapor deposition (iCVD) to improve its wettability and overall biocompatibility. The iCVD functionalized MAP-PLA composite patch showed superior cell interaction of human osteoblasts. Following the surface functionalization by p(HEMA-co-EGDMA) via the iCVD technique, a highly hydrophilic patch was achieved without tailoring any morphological and structural properties. Moreover, the iCVD modified composite patch exhibited ideal cell adhesion for human osteoblasts, thus making the proposed patch suitable for potential biomedical applications including bone tissue engineering, especially in the fields of dentistry and orthopedy.
当前的研究旨在描述通过将海藻粉（MAPs）掺入聚乳酸（PLA）中来制备用于骨组织工程的复合贴片。通过引发化学气相沉积（iCVD）用共聚物聚（甲基丙烯酸2-羟乙酯-共-乙二醇二甲基丙烯酸酯）（p(HEMA-co-EGDMA)）对制备的复合贴片进行功能化，以改善其润湿性和整体生物相容性。iCVD功能化的MAP-PLA复合贴片显示出与人成骨细胞的优异细胞相互作用。通过iCVD技术用p(HEMA-co-EGDMA)进行表面功能化后，无需调整任何形态和结构特性即可获得高度亲水性的贴片。此外，iCVD改性的复合贴片对人成骨细胞表现出理想的细胞粘附性，因此使所提出的贴片适用于包括骨组织工程在内的潜在生物医学应用，尤其是在牙科和矫形领域。
