Liang Wenqing, Zhou Chao, Bai Juqin, Zhang Hongwei, Long Hengguo, Jiang Bo, Wang Jiangwei, Huang Xiaogang, Zhang Hengjian, Zhao Jiayi
Department of Orthopaedics, Zhoushan Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Zhoushan, 316000, China.
Department of Orthopedics, Zhoushan Guanghua Hospital, Zhoushan, 316000, China.
Heliyon. 2024 Aug 10;10(16):e36152. doi: 10.1016/j.heliyon.2024.e36152. eCollection 2024 Aug 30.
The biomedical application of biodegradable polymers for addressing bone-related diseases has garnered considerable attention in recent years. Advances in material technology have expanded the repertoire of materials suitable for orthopedic implants, with nanomaterials playing a pivotal role in replicating crucial surface properties akin to natural tissues. This comprehensive review explores the evaluation of bioactive glass ceramics, shedding light on their properties and applications. The synthesis of composites through composite manufacturing has emerged as a strategy to enhance biocompatibility and biomechanical characteristics. They are addressing challenges associated with conventional implants and nanomaterials, whether in the form of functional nano coatings or nanostructured surfaces, present opportunities to refine implant techniques. Novel developments in orthopedic biomaterials, such as smart biomaterials, porous structures, and 3D implants, offer stimuli-responsive behavior to achieve desired implant shapes and characteristics. Bioactive and biodegradable porous polymer/inorganic composite materials are explored for bone tissue engineering scaffolds, aiming to promote bone formation and regeneration. As a prospective direction, the integration of stem cells into scaffolds hints at the creation of next-generation synthetic/living hybrid biomaterials, displaying high adaptability in biological settings. This review establishes a foundation for nanotechnology-driven biomaterials by elucidating fundamental design factors crucial for orthopedic implant performance and their response to cell differentiation, proliferation, and adhesion.
近年来，可生物降解聚合物在治疗骨相关疾病方面的生物医学应用受到了广泛关注。材料技术的进步扩大了适用于骨科植入物的材料种类，其中纳米材料在复制类似于天然组织的关键表面特性方面发挥着关键作用。这篇综述探讨了生物活性玻璃陶瓷的评估，阐明了它们的特性和应用。通过复合材料制造合成复合材料已成为一种提高生物相容性和生物力学特性的策略。它们正在应对与传统植入物相关的挑战，而无论是功能性纳米涂层还是纳米结构表面形式的纳米材料，都为改进植入技术提供了机会。骨科生物材料的新进展，如智能生物材料、多孔结构和3D植入物，具有刺激响应行为，以实现所需的植入物形状和特性。探索了用于骨组织工程支架的生物活性和可生物降解的多孔聚合物/无机复合材料，旨在促进骨形成和再生。作为一个前瞻性方向，将干细胞整合到支架中暗示着创建下一代合成/生物混合生物材料，在生物环境中显示出高适应性。这篇综述通过阐明对骨科植入物性能及其对细胞分化、增殖和粘附的反应至关重要的基本设计因素，为纳米技术驱动的生物材料奠定了基础。
