Kaur Avneet, Bhalla Vijay, Salahuddin Mohammed, Rahman Syed O, Pottoo Faheem H
Department of Pharmaceutical Chemistry, SGT College of Pharmacy, Shree Guru Gobind Singh Tricentenary University, Gurgaon, Haryana-122505, India.
Department of Animal House, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam-31441, Saudi Arabia.
Curr Pharm Des. 2021;27(33):3551-3565. doi: 10.2174/1381612827999210111185608.
Coronavirus was first discovered during the year 1930 and since then, various coronaviruses like HKU1, MERS-CoV , NL63 and SARS-CoV-2 have been found to infect humans. The COVID-19 pandemic caused by SARS-CoV-2 is spreading at an alarming rate, thereby creating a health emergency around the world. SARS-CoV2 is reported to be originated from a wet animal market of Wuhan, China. Since then, the world is searching for effective ways to manage and treat the COVID-19 infection. The infections have already multiplied with several folds compared to the number of persons infected by Middle East Respiratory Syndrome Coronavirus and Severe Acute Respiratory Syndrome. In order to fill the gap of knowledge about this virus, several pieces of evidence are required to control it so more lives could be saved. The present review is based on the publicly available literature in order to explore the knowledge regarding epidemiology, virology, diagnosis, clinical features, pharmacological and therapeutic ways to treat the novel coronavirus. This can be helpful in offering novel insights and potential therapeutics for fighting this disease.
冠状病毒最早于1930年被发现，从那时起，人们发现多种冠状病毒，如HKU1、中东呼吸综合征冠状病毒（MERS-CoV）、NL63和严重急性呼吸综合征冠状病毒2（SARS-CoV-2）可感染人类。由SARS-CoV-2引起的新型冠状病毒肺炎疫情正在以惊人的速度蔓延，从而在全球引发了一场卫生紧急事件。据报道，SARS-CoV-2起源于中国武汉的一个湿货市场。从那时起，全世界都在寻找有效方法来管理和治疗新型冠状病毒肺炎感染。与中东呼吸综合征冠状病毒和严重急性呼吸综合征的感染人数相比，新型冠状病毒肺炎的感染人数已经增加了数倍。为了填补关于这种病毒的知识空白，需要多条证据来控制它，以便挽救更多生命。本综述基于公开可用的文献，以探索关于新型冠状病毒的流行病学、病毒学、诊断、临床特征、药理学和治疗方法的知识。这有助于为抗击这种疾病提供新的见解和潜在的治疗方法。
