Gilbard J P, Rossi S R
Cornea Research Unit, Eye Research Institute, Boston, MA 02114.
Ophthalmology. 1992 Apr;99(4):600-4. doi: 10.1016/s0161-6420(92)31929-3.
Thirty-two rabbits with monocular surgically induced keratoconjunctivitis sicca (KCS) underwent masked treatment for 12 weeks with 1 of 4 artificial tear solutions. Disease in each group of treated rabbits was compared with disease in untreated KCS controls. One of the solutions tested was a unique electrolyte-based formulation shown previously to preserve normal goblet-cell density after extended exposure in normal rabbits. Only the electrolyte-based solution decreased elevated tear osmolarity and sodium after 9 weeks of treatment (P less than 0.05). At 20 weeks, mean corneal glycogen and conjunctival goblet-cell density in eyes treated with the electrolyte-based solution increased significantly relative to untreated KCS controls (P less than 0.01). With the other three solutions, mean glycogen levels and goblet-cell densities were either decreased relative to untreated KCS controls (P less than 0.05) or were unchanged. The electrolyte-based solution is the first treatment to increase corneal glycogen and conjunctival goblet cells in a rabbit model of KCS.
32只通过手术诱导产生单眼干燥性角结膜炎（KCS）的兔子，用4种人工泪液溶液中的一种进行了为期12周的盲法治疗。将每组接受治疗的兔子的病情与未治疗的KCS对照兔子的病情进行比较。所测试的溶液之一是一种独特的基于电解质的配方，先前已证明在正常兔子长时间暴露后能保持正常的杯状细胞密度。仅基于电解质的溶液在治疗9周后降低了升高的泪液渗透压和钠含量（P<0.05）。在20周时，与未治疗的KCS对照相比，用基于电解质的溶液治疗的眼睛的平均角膜糖原和结膜杯状细胞密度显著增加（P<0.01）。使用其他三种溶液时，平均糖原水平和杯状细胞密度相对于未治疗的KCS对照要么降低（P<0.05），要么没有变化。基于电解质的溶液是在KCS兔子模型中第一种能增加角膜糖原和结膜杯状细胞的治疗方法。
