Gu Jianzhong, Zhan Yu, Zhuo Lvjia, Zhang Qin, Li Guohua, Li Qiujie, Qi Shasha, Zhu Jinyu, Lv Qun, Shen Yingying, Guo Yong, Liu Shuiping, Xie Tian, Sui Xinbing
College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China.
Department of Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou, 310006, Zhejiang, China.
Cell Biosci. 2021 Jan 11;11(1):15. doi: 10.1186/s13578-020-00513-0.
MA methyltransferases, acting as a writer in N6-methyladenosine, have attracted wide attention due to their dynamic regulation of life processes. In this review, we first briefly introduce the individual components of mA methyltransferases and explain their close connections to each other. Then, we concentrate on the extensive biological functions of mA methyltransferases, which include cell growth, nerve development, osteogenic differentiation, metabolism, cardiovascular system homeostasis, infection and immunity, and tumour progression. We summarize the currently unresolved problems in this research field and propose expectations for mA methyltransferases as novel targets for preventive and curative strategies for disease treatment in the future.
N6-甲基腺苷的“书写者”——甲基转移酶（MA甲基转移酶），因其对生命过程的动态调控而备受广泛关注。在本综述中，我们首先简要介绍了mA甲基转移酶的各个组成部分，并解释了它们彼此之间的紧密联系。然后，我们重点关注mA甲基转移酶广泛的生物学功能，包括细胞生长、神经发育、成骨分化、代谢、心血管系统稳态、感染与免疫以及肿瘤进展。我们总结了该研究领域目前尚未解决的问题，并对mA甲基转移酶作为未来疾病预防和治疗策略的新靶点提出了期望。
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