腹部肥胖与心血管疾病风险：31项前瞻性研究的剂量反应荟萃分析。

Abdominal obesity and risk of CVD: a dose-response meta-analysis of thirty-one prospective studies.

作者信息

Xue Ran, Li Qianwen, Geng Yaping, Wang Hao, Wang Fudi, Zhang Shenshen

机构信息

Department of Precision Nutrition Innovation Center, Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.

The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

出版信息

Br J Nutr. 2021 Nov 14;126(9):1420-1430. doi: 10.1017/S0007114521000064. Epub 2021 Jan 12.

DOI:10.1017/S0007114521000064

PMID:33431092

Abstract

This meta-analysis aimed to study the relationship between abdominal obesity and the risk of CVD by waist circumference (WC), waist:hip ratio (WHR) and waist:height ratio (WHtR). We systematically searched PubMed, Embase and Web of Science. Prospective studies that estimated cardiovascular events by WC, WHR and WHtR were included in this study. Pooled relative risks with 95 % CI were calculated using random effects models. A total of thirty-one studies were included in the meta-analysis, including 669 560 participants and 25 214 cases. Compared the highest with the lowest category of WC, WHR and WHtR, the summary risk ratios were 1·43 (95 % CI, 1·30, 1·56, P < 0·001), 1·43 (95 % CI, 1·33, 1·54, P < 0·001) and 1·57 (95 % CI, 1·37, 1·79, P < 0·001), respectively. The linear dose-response analysis revealed that the risk of CVD increased by 3·4 % for each 10 cm increase of WC, and by 3·5 and 6·0 % for each 0·1 unit increase of WHR and WHtR in women, respectively. In men, the risk of CVD increased by 4·0 % for each 10 cm increase of WC, and by 4·0 and 8·6 % for each 0·1 unit increase of WHR and WHtR, respectively. Collectively, abdominal obesity is associated with an increased risk of CVD. WC, WHR and WHtR are good indicators for the prediction of CVD.

摘要

本荟萃分析旨在通过腰围（WC）、腰臀比（WHR）和腰高比（WHtR）研究腹型肥胖与心血管疾病（CVD）风险之间的关系。我们系统检索了PubMed、Embase和科学网。本研究纳入了通过WC、WHR和WHtR评估心血管事件的前瞻性研究。使用随机效应模型计算合并相对风险及95%置信区间（CI）。荟萃分析共纳入31项研究，包括669560名参与者和25214例病例。将WC、WHR和WHtR的最高类别与最低类别进行比较，汇总风险比分别为1.43（95%CI，1.30，1.56，P<0.001）、1.43（95%CI，1.33，1.54，P<0.001）和1.57（95%CI，1.37，1.79，P<0.001）。线性剂量反应分析显示，女性WC每增加10 cm，CVD风险增加3.4%；WHR和WHtR每增加0.1个单位，CVD风险分别增加3.5%和6.0%。在男性中，WC每增加10 cm，CVD风险增加4.0%；WHR和WHtR每增加0.1个单位，CVD风险分别增加4.0%和8.6%。总体而言，腹型肥胖与CVD风险增加相关。WC、WHR和WHtR是预测CVD的良好指标。