Wellcome Trust MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Nat Metab. 2021 Feb;3(2):142-148. doi: 10.1038/s42255-020-00327-x. Epub 2021 Jan 11.
Glucagon like peptide-1 (GLP-1), a peptide hormone from the intestinal tract, plays a central role in the coordination of postprandial glucose homeostasis through actions on insulin secretion, food intake and gut motility. GLP-1 forms the basis for a variety of current drugs for the treatment of type 2 diabetes and obesity, as well as new agents currently being developed. Here, we provide a concise overview of the core physiology of GLP-1 secretion and action, and the role of the peptide in human health, disease and therapeutics.
胰高血糖素样肽 1（GLP-1）是一种来自肠道的肽类激素，通过对胰岛素分泌、食物摄入和肠道蠕动的作用，在协调餐后血糖稳态方面发挥着核心作用。GLP-1 是目前用于治疗 2 型糖尿病和肥胖症的各种药物以及正在开发的新药物的基础。在这里，我们简要概述了 GLP-1 分泌和作用的核心生理学，以及该肽在人类健康、疾病和治疗中的作用。
