Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.
Department of Dermatology, Medical University of Graz, Graz, Austria.
J Anat. 2021 Jun;238(6):1355-1358. doi: 10.1111/joa.13394. Epub 2021 Jan 11.
Rosacea is a chronic, often progressive disorder characterized by facial erythema, telangiectasias, papules, pustules, and/or rhinophyma. In this study, we investigated the tissue structure in rosacea compared to controls. We performed a case-control study between five patients with mild-to-moderate erythematotelangiectatic rosacea (ETR) and five matched controls. Facial biopsy samples from rosacea patients and controls were stained with picrosirius red for collagen and CD31 for microvessel identification. Mean collagen content was significantly greater in control samples (19.603% ±8.821%) compared to rosacea samples (16.812% ± 7.787%, p = 0.030). In contrast, mean microvessel density was significantly higher in rosacea patients (4.775 E-5 ± 1.493 E-5 µm ) compared to controls (2.559 E-5 ± 8.732 E-6 µm , p = 0.004). Mean microvessel lumen area was also significantly higher in rosacea patients (491.710 ± 610.188 µm ) compared to controls (347.879 ± 539.624 µm , p = 0.003). We identified a correlation between decreased collagen content and increased microvessel size and density in rosacea patients that was not observed in controls. These structural changes to the dermal matrix may contribute to the characteristic vessel growth and dilation in rosacea.
酒渣鼻是一种慢性、常进展性疾病，其特征为面部红斑、毛细血管扩张、丘疹、脓疱和/或鼻赘。在这项研究中，我们研究了酒渣鼻组织结构与对照组的差异。我们进行了一项病例对照研究，纳入 5 名轻度至中度红斑毛细血管扩张型酒渣鼻（ETR）患者和 5 名匹配的对照。对酒渣鼻患者和对照的面部活检样本进行皮尔斯天狼星红染色以鉴定胶原，CD31 染色以鉴定微血管。与酒渣鼻样本（16.812%±7.787%）相比，对照组的平均胶原含量显著更高（19.603%±8.821%）（p=0.030）。相比之下，酒渣鼻患者的平均微血管密度显著更高（4.775 E-5±1.493 E-5µm），而对照组为（2.559 E-5±8.732 E-6µm）（p=0.004）。酒渣鼻患者的平均微血管管腔面积也显著更高（491.710±610.188µm），而对照组为（347.879±539.624µm）（p=0.003）。我们发现，与对照组不同，酒渣鼻患者的胶原含量减少与微血管大小和密度增加之间存在相关性。真皮基质的这些结构变化可能导致酒渣鼻中特征性的血管生长和扩张。
