Rosina Paolo, Zamperetti Maria Rosa, Giovannini Andrea, Chieregato Carlo, Girolomoni Giampiero
Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy.
J Am Acad Dermatol. 2006 Jan;54(1):100-4. doi: 10.1016/j.jaad.2005.10.009. Epub 2005 Nov 11.
Rosacea is a common chronic dermatosis that involves the cutaneous microvasculature of the face. There are no objective measures for assessing the severity of erythematotelangiectatic rosacea.
Our purpose was to characterize and provide objective measures of vessel changes in erythematotelangiectatic rosacea by videocapillaroscopy.
We compared 30 patients with erythematotelangiectatic rosacea with 30 age- and sex-matched patients with facial seborrheic dermatitis and 30 healthy control subjects. Videocapillaroscopy was performed both on the cheeks and on the nailfold region. The analyzed parameters of the face were morphological (background color, vessel irregularities) and quantitative (polygonal net perimeter, telangiectasia, and vessel diameters).
Characteristic alterations of skin vessels were observed in facial rosacea, with a pattern distinct from that of facial seborrheic dermatitis. In particular, rosacea showed neoangiogenesis and significantly larger polygons (13.21 +/- 3 vs 7.8 +/- 3 mm; mean +/- standard deviation, P < .001), more prominent telangiectases (267.8 +/- 108 vs 118.2 +/- 35 microm; P < .001) and larger mean vessel diameter (46.71 +/- 9 vs 24 +/- 10 microm; P < .001) compared with seborrheic dermatitis. Seborrheic dermatitis displayed more polygon irregularities and vessel tortuosity. In contrast, no differences were found in the nailfold region.
Vessel irregularities and overall erythema may be difficult to quantify.
Videocapillaroscopy may represent a valid adjunctive method in the early diagnosis and measurement of erythematotelangiectatic rosacea.
酒渣鼻是一种常见的慢性皮肤病，累及面部皮肤微血管。目前尚无评估红斑毛细血管扩张型酒渣鼻严重程度的客观方法。
我们的目的是通过视频毛细血管显微镜检查来描述红斑毛细血管扩张型酒渣鼻血管变化的特征并提供客观测量方法。
我们将30例红斑毛细血管扩张型酒渣鼻患者与30例年龄和性别匹配的面部脂溢性皮炎患者以及30名健康对照者进行比较。在脸颊和甲襞区域进行视频毛细血管显微镜检查。对面部分析的参数包括形态学参数（背景颜色、血管不规则性）和定量参数（多边形网周长、毛细血管扩张和血管直径）。
在面部酒渣鼻中观察到皮肤血管的特征性改变，其模式与面部脂溢性皮炎不同。特别是，与脂溢性皮炎相比，酒渣鼻显示出新生血管形成，多边形明显更大（13.21±3对7.8±3毫米；平均值±标准差，P<.001），毛细血管扩张更明显（267.8±108对118.2±35微米；P<.001），平均血管直径更大（46.71±9对24±10微米；P<.001）。脂溢性皮炎表现出更多的多边形不规则和血管迂曲。相比之下，在甲襞区域未发现差异。
血管不规则性和整体红斑可能难以量化。
视频毛细血管显微镜检查可能是红斑毛细血管扩张型酒渣鼻早期诊断和测量的一种有效辅助方法。
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