1Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
2Vietnamese-German Center for Medical Research, Hanoi, Vietnam.
Am J Trop Med Hyg. 2021 Jan 11;104(3):1041-1044. doi: 10.4269/ajtmh.20-1282.
Hypoxemia is readily detectable by assessing SpO2 levels, and these are important in optimizing COVID-19 patient management. Hyperlactatemia is a marker of tissue hypoxia, particularly in patients with increased oxygen requirement and microvascular obstruction. We monitored peripheral venous lactate concentrations in hospitalized patients with moderate to severe COVID-19 (n = 18) and in mild ambulatory COVID-19 patients in home quarantine (n = 16). Whole blood lactate decreased significantly during the clinical course and recovery in hospitalized patients (P = 0.008). The blood lactate levels were significantly higher in hospitalized patients than ambulatory patients (day 1: hospitalized versus ambulatory patients P = 0.002; day 28: hospitalized versus ambulatory patients P = < 0.0001). Elevated lactate levels may be helpful in risk stratification, and serial monitoring of lactate may prove useful in the care of hospitalized COVID-19 patients.
低氧血症可通过评估 SpO2 水平来快速检测，这些对于优化 COVID-19 患者管理非常重要。高乳酸血症是组织缺氧的标志物，特别是在需要增加氧气和微血管阻塞的患者中。我们监测了 18 例中重度 COVID-19 住院患者和 16 例轻症居家隔离 COVID-19 门诊患者的外周静脉血乳酸浓度。在住院患者的临床过程和恢复期间，全血乳酸显著下降（P = 0.008）。住院患者的血乳酸水平显著高于门诊患者（第 1 天：住院患者与门诊患者 P = 0.002；第 28 天：住院患者与门诊患者 P = <0.0001）。乳酸水平升高可能有助于风险分层，连续监测乳酸可能对 COVID-19 住院患者的护理有用。
