Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.
Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.
Front Immunol. 2022 Mar 23;13:868679. doi: 10.3389/fimmu.2022.868679. eCollection 2022.
Coronavirus disease 2019 (COVID-19), an infectious respiratory disease propagated by a new virus known as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has resulted in global healthcare crises. Emerging evidence from patients with COVID-19 suggests that endothelial cell damage plays a central role in COVID-19 pathogenesis and could be a major contributor to the severity and mortality of COVID-19. Like other infectious diseases, the pathogenesis of COVID-19 is closely associated with metabolic processes. Lactate, a potential biomarker in COVID-19, has recently been shown to mediate endothelial barrier dysfunction. In this review, we provide an overview of cardiovascular injuries and metabolic alterations caused by SARS-CoV-2 infection. We also propose that lactate plays a potential role in COVID-19-driven endothelial cell injury.
新型冠状病毒病（COVID-19）是一种由新型冠状病毒（SARS-CoV-2）引起的传染性呼吸道疾病，已造成全球卫生保健危机。来自 COVID-19 患者的新证据表明，内皮细胞损伤在 COVID-19 发病机制中起核心作用，可能是导致 COVID-19 严重程度和死亡率的主要因素。与其他传染病一样，COVID-19 的发病机制与代谢过程密切相关。乳酸是 COVID-19 的一种潜在生物标志物，最近已被证明可介导内皮屏障功能障碍。在这篇综述中，我们概述了 SARS-CoV-2 感染引起的心血管损伤和代谢改变。我们还提出乳酸可能在 COVID-19 驱动的内皮细胞损伤中发挥作用。
