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了解 COVID-19 相关的血管内皮功能障碍：PIEZO1 作为潜在治疗靶点的作用。

Understanding COVID-19-associated endothelial dysfunction: role of PIEZO1 as a potential therapeutic target.

机构信息

Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China.

出版信息

Front Immunol. 2024 Feb 29;15:1281263. doi: 10.3389/fimmu.2024.1281263. eCollection 2024.

DOI:10.3389/fimmu.2024.1281263
PMID:38487535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10937424/
Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Due to its high infectivity, the pandemic has rapidly spread and become a global health crisis. Emerging evidence indicates that endothelial dysfunction may play a central role in the multiorgan injuries associated with COVID-19. Therefore, there is an urgent need to discover and validate novel therapeutic strategies targeting endothelial cells. PIEZO1, a mechanosensitive (MS) ion channel highly expressed in the blood vessels of various tissues, has garnered increasing attention for its potential involvement in the regulation of inflammation, thrombosis, and endothelial integrity. This review aims to provide a novel perspective on the potential role of PIEZO1 as a promising target for mitigating COVID-19-associated endothelial dysfunction.

摘要

新型冠状病毒肺炎（COVID-19）是由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染引起的传染病。由于其高传染性，该大流行迅速蔓延，成为全球卫生危机。新出现的证据表明，内皮功能障碍可能在与 COVID-19 相关的多器官损伤中起核心作用。因此，迫切需要发现和验证针对内皮细胞的新型治疗策略。PIEZO1 是一种机械敏感（MS）离子通道，在各种组织的血管中高度表达，其在炎症、血栓形成和内皮完整性调节中的潜在作用引起了越来越多的关注。本综述旨在为 PIEZO1 作为减轻 COVID-19 相关内皮功能障碍的有前途的靶点提供新的视角。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10937424/8ddf82d1cb4f/fimmu-15-1281263-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10937424/a01a143606cf/fimmu-15-1281263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10937424/8ddf82d1cb4f/fimmu-15-1281263-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10937424/a01a143606cf/fimmu-15-1281263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10937424/8ddf82d1cb4f/fimmu-15-1281263-g002.jpg

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Mechanical activation of lung epithelial cells through the ion channel Piezo1 activates the metalloproteinases ADAM10 and ADAM17 and promotes growth factor and adhesion molecule release.通过离子通道Piezo1对肺上皮细胞进行机械激活，可激活金属蛋白酶ADAM10和ADAM17，并促进生长因子和黏附分子的释放。
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