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Stem cell-derived three-dimensional (organoid) models of Alzheimer's disease: a precision medicine approach.

作者信息

Kim Sujung Jun, Li Jiaxin, Mahairaki Vasiliki

机构信息

Department of Neurology; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

出版信息

Neural Regen Res. 2021 Aug;16(8):1546-1547. doi: 10.4103/1673-5374.303019.

DOI:10.4103/1673-5374.303019
PMID:33433475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8323699/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5916/8323699/1d583d2b4ab8/NRR-16-1546-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5916/8323699/1d583d2b4ab8/NRR-16-1546-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5916/8323699/1d583d2b4ab8/NRR-16-1546-g001.jpg

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本文引用的文献

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Human Forebrain Organoids from Induced Pluripotent Stem Cells: A Novel Approach to Model Repair of Ionizing Radiation-Induced DNA Damage in Human Neurons.人诱导多能干细胞衍生的前脑类器官:模拟人神经元中电离辐射诱导的 DNA 损伤修复的新方法。
Radiat Res. 2020 Aug 1;194(2):191-198. doi: 10.1667/RR15567.1.
2
A Three-Dimensional Alzheimer's Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1.一种使用携带PSEN1基因A246E突变的诱导多能干细胞衍生神经元构建的三维阿尔茨海默病细胞培养模型。
Front Cell Neurosci. 2020 Jun 12;14:151. doi: 10.3389/fncel.2020.00151. eCollection 2020.
3
Deciphering Alzheimer's disease: predicting new therapeutic strategies via improved understanding of biology and pathogenesis.
解读阿尔茨海默病:通过深入了解生物学和发病机制来预测新的治疗策略。
Expert Opin Ther Targets. 2020 Sep;24(9):859-868. doi: 10.1080/14728222.2020.1790530. Epub 2020 Jul 13.
4
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.一个包含大量同基因 APP 和 PSEN1 突变的人 iPSC 神经元的大面板揭示了由 APP β-CTFs 介导的共享内体异常,而不是 Aβ。
Neuron. 2019 Oct 23;104(2):256-270.e5. doi: 10.1016/j.neuron.2019.07.010. Epub 2019 Aug 12.
5
Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells.脑区特异性球体与同基因小胶质细胞样细胞的功能化。
Sci Rep. 2019 Jul 30;9(1):11055. doi: 10.1038/s41598-019-47444-6.
6
High-resolution 3D imaging of fixed and cleared organoids.固定和清除类器官的高分辨率 3D 成像。
Nat Protoc. 2019 Jun;14(6):1756-1771. doi: 10.1038/s41596-019-0160-8. Epub 2019 May 3.
7
Modeling amyloid beta and tau pathology in human cerebral organoids.在人类脑类器官中模拟淀粉样β和tau 病理学。
Mol Psychiatry. 2018 Dec;23(12):2363-2374. doi: 10.1038/s41380-018-0229-8. Epub 2018 Aug 31.
8
An in vivo model of functional and vascularized human brain organoids.体内功能性和血管化人脑类器官模型。
Nat Biotechnol. 2018 Jun;36(5):432-441. doi: 10.1038/nbt.4127. Epub 2018 Apr 16.
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PRECISION MEDICINE - The Golden Gate for Detection, Treatment and Prevention of Alzheimer's Disease.精准医学——检测、治疗和预防阿尔茨海默病的黄金大门。
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