Ding Luo-Gang, Wang Song, Yao Bing-Jian, Li Fei, Li Yan-An, Zhao Guo-Yan, Dong Yu-Bin
College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan, 250014, P. R. China.
Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, 250014, P. R. China.
Adv Healthc Mater. 2021 Apr;10(8):e2001821. doi: 10.1002/adhm.202001821. Epub 2021 Jan 12.
Chronic wound infections resulting from severe bacterial invasion have become a major medical threat worldwide. Herein, we report a large-area, homogeneous, and self-standing porphyrin-covalent organic framework (COF)-based membrane with encapsulated ibuprofen (IBU) via an in situ interfacial polymerization and impregnation approach. The obtained IBU@DhaTph-membrane exhibits highly effective antibacterial and anti-inflammatory effects via synergistic light-induced singlet oxygen ( O ) generation and controllable IBU release, which is well supported by in vitro experiments. In addition, the IBU@DhaTph-membrane-based biocompatible "band-aid" type dressing is fabricated, and its excellent anti-infection and tissue remodeling activities are fully evidenced by in vivo chronic wound-healing experiments. This study may inspire and promote the fabrication of many more new types of COF-based multifunctional biomaterials for various skin injuries in clinical medicine.
由严重细菌入侵引起的慢性伤口感染已成为全球主要的医学威胁。在此，我们报道了一种通过原位界面聚合和浸渍方法制备的大面积、均匀且自立的基于卟啉共价有机框架（COF）的膜，其中包封了布洛芬（IBU）。所获得的IBU@DhaTph膜通过协同光诱导单线态氧（O）生成和可控的IBU释放表现出高效的抗菌和抗炎作用，体外实验充分证明了这一点。此外，制备了基于IBU@DhaTph膜的生物相容性“创可贴”型敷料，体内慢性伤口愈合实验充分证明了其优异的抗感染和组织重塑活性。这项研究可能会启发并促进更多新型基于COF的多功能生物材料的制备，用于临床医学中的各种皮肤损伤。
