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用于伤口愈合和抗菌应用的共价有机框架（COF）的最新进展。

Recent advances in covalent organic frameworks (COFs) for wound healing and antimicrobial applications.

作者信息

Mohajer Fatemeh, Mohammadi Ziarani Ghodsi, Badiei Alireza, Iravani Siavash, Varma Rajender S

机构信息

Department of Organic Chemistry, Faculty of Chemistry, Alzahra University Tehran Iran

School of Chemistry, College of Science, University of Tehran Iran.

出版信息

RSC Adv. 2023 Mar 13;13(12):8136-8152. doi: 10.1039/d2ra07194k. eCollection 2023 Mar 8.

DOI:10.1039/d2ra07194k
PMID:36922952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10009765/
Abstract

Covalent organic frameworks (COFs) are crystal-like organic structures such as cartography buildings prepared from appropriately pre-designed construction block precursors. Moreover, after the expansion of the first COF in 2005, numerous researchers have been developing different materials for versatile applications such as sensing/imaging, cancer theranostics, drug delivery, tissue engineering, wound healing, and antimicrobials. COFs have harmonious pore size, enduring porosity, thermal stability, and low density. In addition, a wide variety of functional groups could be implanted during their construction to provide desired constituents, including antibodies and enzymes. The reticular organic frameworks comprising porous hybrid materials connected a covalent bond have been studied for improving wound healing and dressing applications due to their long-standing antibacterial properties. Several COF-based systems have been planned for controlled drug delivery with wound healing purposes, targeting drugs to efficiently inhibit the growth of pathogenic microorganisms at the wound spot. In addition, COFs can be deployed for combinational therapy using photodynamic and photothermal antibacterial therapy along with drug delivery for healing chronic wounds and bacterial infections. Herein, the most recent advancements pertaining to the applications of COF-based systems against bacterial infections and for wound healing are considered, concentrating on challenges and future guidelines.

摘要

共价有机框架（COFs）是类似晶体的有机结构，就像由经过适当预先设计的结构单元前体构建的制图建筑。此外，自2005年首个COF问世以来，众多研究人员一直在开发用于多种应用的不同材料，如传感/成像、癌症诊疗、药物递送、组织工程、伤口愈合和抗菌等。COFs具有均匀的孔径、持久的孔隙率、热稳定性和低密度。此外，在其构建过程中可以引入各种各样的官能团，以提供所需的成分，包括抗体和酶。由于其长期的抗菌性能，由共价键连接的包含多孔杂化材料的网状有机框架已被研究用于改善伤口愈合和敷料应用。已经设计了几种基于COF的系统用于以伤口愈合为目的的控释药物递送，使药物能够有效抑制伤口部位致病微生物的生长。此外，COFs可用于联合治疗，采用光动力和光热抗菌疗法以及药物递送，以治愈慢性伤口和细菌感染。在此，我们考虑了基于COF的系统在对抗细菌感染和伤口愈合应用方面的最新进展，重点关注挑战和未来方向。

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