Black R E, Levine M M, Clements M L, Hughes T P, Blaser M J
Department of Medicine, University of Maryland School of Medicine, Baltimore.
J Infect Dis. 1988 Mar;157(3):472-9. doi: 10.1093/infdis/157.3.472.
Two strains of Campylobacter jejuni ingested by 111 adult volunteers, in doses ranging from 8 x 10(2) to 2 x 10(9) organisms, caused diarrheal illnesses. Rates of infection increased with dose, but development of illness did not show a clear dose relation. Resulting illnesses with strain A3249 ranged from a few loose stools to dysentery, with an average of five diarrheal stools and a volume of 509 mL. Infection with strain 81-176 was more likely to cause illness, and these illnesses were more severe, with an average of 15 stools and 1484 mL of total stool volume. All patients had fecal leukocytes. The dysenteric nature of the illness indicates that the pathogenesis of C. jejuni infection includes tissue inflammation. Ill volunteers developed a serum antibody response to the C. jejuni group antigen and were protected from subsequent illness but not infection with the same strain.
111名成年志愿者摄入了两种空肠弯曲菌菌株，剂量范围为8×10²至2×10⁹个菌体，均引发了腹泻疾病。感染率随剂量增加，但发病情况并未呈现出明确的剂量关系。A3249菌株导致的疾病从少量稀便到痢疾不等，平均有5次腹泻，粪便量为509毫升。81 - 176菌株感染更易引发疾病，且病情更严重，平均有15次排便，粪便总量为1484毫升。所有患者粪便中均有白细胞。疾病的痢疾性质表明空肠弯曲菌感染的发病机制包括组织炎症。患病志愿者对空肠弯曲菌属抗原产生了血清抗体反应，并对随后的疾病具有抵抗力，但仍会感染同一菌株。
