Kang Chung-Min, Seong Saemi, Song Je Seon, Shin Yooseok
Department of Pediatric Dentistry, College of Dentistry, Yonsei University, Seoul 03722, Korea.
Department of Conservative Dentistry and Oral Science Research Center, College of Dentistry, Yonsei University, Seoul 03722, Korea.
Materials (Basel). 2021 Jan 8;14(2):305. doi: 10.3390/ma14020305.
The use of hydraulic silicate cements (HSCs) for vital pulp therapy has been found to release calcium and hydroxyl ions promoting pulp tissue healing and mineralized tissue formation. The present study investigated whether HSCs such as mineral trioxide aggregate (MTA) affect their biological and antimicrobial properties when used as long-term pulp protection materials. The effect of variables on treatment outcomes of three HSCs (ProRoot MTA, OrthoMTA, and RetroMTA) was evaluated clinically and radiographically over a 48-78 month follow-up period. Survival analysis was performed using Kaplan-Meier survival curves. Fisher's exact test and Cox regression analysis were used to determine hazard ratios of clinical variables. The overall success rate of MTA partial pulpotomy was 89.3%; Cumulative success rates of the three HSCs were not statistically different when analyzed by Cox proportional hazard regression analysis. None of the investigated clinical variables affected success rates significantly. These HSCs showed favorable biocompatibility and antimicrobial properties in partial pulpotomy of permanent teeth in long-term follow-up, with no statistical differences between clinical factors.
已发现使用水硬性硅酸盐水泥（HSCs）进行活髓治疗可释放钙离子和氢氧根离子，促进牙髓组织愈合和矿化组织形成。本研究调查了诸如矿物三氧化物凝聚体（MTA）等HSCs用作长期牙髓保护材料时是否会影响其生物学和抗菌性能。在48 - 78个月的随访期内，通过临床和影像学评估了变量对三种HSCs（ProRoot MTA、OrthoMTA和RetroMTA）治疗结果的影响。使用Kaplan - Meier生存曲线进行生存分析。采用Fisher精确检验和Cox回归分析来确定临床变量的风险比。MTA部分牙髓切断术的总体成功率为89.3%；通过Cox比例风险回归分析时，三种HSCs的累积成功率无统计学差异。所研究的临床变量均未显著影响成功率。在长期随访中，这些HSCs在恒牙部分牙髓切断术中显示出良好的生物相容性和抗菌性能，临床因素之间无统计学差异。
