Wang Jing-Hua, Lee Sung-Bae, Lee Dong-Soo, Son Chang-Gue
Institute of Bioscience & Integrative Medicine, Daejeon University, 75, Daedeok-daero 176, Seo-gu, Daejeon 35235, Korea.
Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 64, Daeheung-ro, Jung-gu, Daejeon 34943, Korea.
Antioxidants (Basel). 2021 Jan 8;10(1):77. doi: 10.3390/antiox10010077.
Oxidative stress plays a pivotal role in the progression of chronic hepatitis B; however, it is unclear whether the status of blood oxidative stress and antioxidant components differs depending on the degree of hepatic fibrosis. To explore the relationship between oxidative stress/antioxidant capacity and the extent of hepatic fibrosis, fifty-four subjects with liver fibrosis (5.5 ≤ liver stiffness measurement (LSM) score ≤ 16.0 kPa) by chronic hepatitis B virus (HBV) were analyzed. From the analysis of eight kinds of serum oxidative stress/antioxidant profiles and liver fibrosis degrees, the level of total antioxidant capacity (TAC) reflected a negative correlation with the severity of hepatic fibrosis (Pearson correlation, r = -0.35, = 0.01). Moreover, TAC showed higher sensitivity (73.91%) than the aspartate transaminase (AST) to platelet ratio index (APRI, 56.52%) in the receiver operating characteristic (ROC) curves. Interestingly, the TAC level finely reflected the fibrosis degree in inactive carriers (HBV DNA < 2000 IU/mL), while the APRI did in active carriers (HBV DNA > 2000 IU/mL). In conclusion, TAC is a promising biomarker for evaluating the progression of liver fibrosis in patients with HBV, and this finding may indicate the involvement of TAC-composing factors in the pathogenesis of hepatic fibrosis in chronic HBV carriers.
氧化应激在慢性乙型肝炎的进展中起关键作用；然而，血液氧化应激和抗氧化成分的状态是否因肝纤维化程度而异尚不清楚。为了探讨氧化应激/抗氧化能力与肝纤维化程度之间的关系，对54例慢性乙型肝炎病毒（HBV）感染所致肝纤维化（肝脏硬度测量（LSM）评分5.5≤LSM评分≤16.0 kPa）患者进行了分析。通过对8种血清氧化应激/抗氧化指标与肝纤维化程度的分析，总抗氧化能力（TAC）水平与肝纤维化严重程度呈负相关（Pearson相关系数，r = -0.35，P = 0.01）。此外，在受试者工作特征（ROC）曲线中，TAC的敏感性（73.91%）高于天冬氨酸转氨酶（AST）与血小板比值指数（APRI，56.52%）。有趣的是，TAC水平能很好地反映非活动携带者（HBV DNA < 2000 IU/mL）的纤维化程度，而APRI能反映活动携带者（HBV DNA > 2000 IU/mL）的纤维化程度。总之，TAC是评估HBV患者肝纤维化进展的一个有前景的生物标志物，这一发现可能表明构成TAC的因子参与了慢性HBV携带者肝纤维化的发病机制。
