Lin Ligen, Zhou Fayang, Shen Shengnan, Zhang Tian
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medicine Sciences, University of Macau, Macau, China.
Planta Med. 2018 Dec;84(18):1318-1333. doi: 10.1055/a-0757-0008. Epub 2018 Oct 12.
Liver fibrosis is a wound-healing response characterized by the accumulation of extracellular matrix following various liver injuries, which results in the deformation of the normal liver architecture and the development of liver cirrhosis and even hepatocellular carcinoma. Numerous and studies indicated that oxidative stress mediates the initiation and progression of liver fibrosis. Overaccumulation of reactive oxygen species disrupts macromolecules, induces necrosis and apoptosis of hepatocytes, stimulates the production of pro-fibrogenic mediators, and directly activates hepatic stellate cells, thereby resulting in liver damage and initiating liver fibrosis. Ameliorating oxidative stress is a potential therapeutic strategy for the treatment of liver fibrosis. Natural antioxidants have attracted increasing attention in treating liver fibrosis due to their safety and efficacy. In this review, the pathogenesis of liver fibrosis and the role of oxidative stress in liver fibrosis were discussed. Naturally occurring antioxidants that can treat and prevent liver fibrosis were summarized. Advances in clinical trials were also presented. The main purpose of this review is to provide a comprehensive and up-to-date knowledge from the biological importance of oxidative stress in liver fibrosis to representative antioxidants for treating liver fibrosis. Naturally occurring antioxidants show a potential for further investigations as lead compounds in fighting liver fibrosis.
肝纤维化是一种伤口愈合反应，其特征是在各种肝脏损伤后细胞外基质的积累，这会导致正常肝脏结构变形以及肝硬化甚至肝细胞癌的发生。大量研究表明，氧化应激介导肝纤维化的起始和进展。活性氧的过度积累会破坏大分子，诱导肝细胞坏死和凋亡，刺激促纤维化介质的产生，并直接激活肝星状细胞，从而导致肝损伤并引发肝纤维化。改善氧化应激是治疗肝纤维化的一种潜在治疗策略。天然抗氧化剂因其安全性和有效性，在治疗肝纤维化方面越来越受到关注。在这篇综述中，讨论了肝纤维化的发病机制以及氧化应激在肝纤维化中的作用。总结了可治疗和预防肝纤维化的天然抗氧化剂。还介绍了临床试验的进展。这篇综述的主要目的是提供从氧化应激在肝纤维化中的生物学重要性到治疗肝纤维化的代表性抗氧化剂的全面且最新的知识。天然抗氧化剂作为对抗肝纤维化的先导化合物具有进一步研究的潜力。
