Department of Metallurgical and Materials Engineering, National Institute of Technology, Warangal, Telangana, 506004, India; Department of Biotechnology, Coupure Links 653, 9000 Gent, Belgium.
Alterno Labs d.o.o, Brnčičeva ulica 29, 1231 Ljubljana, Slovenia; Faculty of Mechanical Engineering, University of Maribor, Smetanova Ulica 17, Maribor SI-2000, Slovenia.
Carbohydr Polym. 2021 Mar 1;255:117487. doi: 10.1016/j.carbpol.2020.117487. Epub 2020 Dec 5.
Metallic implants have dominated the biomedical implant industries for the past century for load-bearing applications, while the polymeric implants have shown great promise for tissue engineering applications. The surface properties of such implants are critical as the interaction of implant surfaces, and the body tissues may lead to unfavourable reactions. Desired implant properties are biocompatibility, corrosion resistance, and antibacterial activity. A polymer coating is an efficient and economical way to produce such surfaces. A lot of research has been carried out on chitosan (CS)-modified metallic and polymer scaffolds in the last decade. Different methods such as electrophoretic deposition, sol-gel methods, dip coating and spin coating, electrospinning, etc. have been utilized to produce CS coatings. However, a systematic review of chitosan coatings on scaffolds focussing on widely employed techniques is lacking. This review surveys literature concerning the current status of orthopaedic applications of CS for the purpose of coatings. In this review, the various preparation methods of coating, and the role of the surface functionalities in determining the efficiency of coatings are discussed. Effect of nanoparticle additions on the polymeric interfaces and in regulating the properties of surface coatings are also investigated in detail.
金属植入物在过去一个世纪中一直主导着生物医学植入物行业，用于承载应用，而聚合物植入物在组织工程应用中显示出巨大的前景。这些植入物的表面特性至关重要，因为植入物表面与身体组织的相互作用可能导致不良反应。理想的植入物特性包括生物相容性、耐腐蚀性和抗菌活性。聚合物涂层是制造这种表面的有效且经济的方法。在过去的十年中，已经对壳聚糖 (CS)-改性的金属和聚合物支架进行了大量研究。已经利用了各种方法，例如电泳沉积、溶胶-凝胶法、浸涂和旋涂、静电纺丝等，来生产 CS 涂层。然而，缺乏针对广泛使用的技术的聚焦于支架上壳聚糖涂层的系统综述。这篇综述调查了有关 CS 用于涂层的骨科应用的文献。在这篇综述中，讨论了涂层的各种制备方法，以及表面官能团在确定涂层效率方面的作用。还详细研究了纳米颗粒添加对聚合物界面和调节表面涂层性质的影响。
