镧系元素（III）-磷配合物的合成及肿瘤细胞摄取研究。
Synthesis and tumour cell uptake studies of gadolinium(III)-phosphonium complexes.
机构信息
School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.
The University of Sydney Nano Institute, Sydney, NSW, 2006, Australia.
出版信息
Sci Rep. 2021 Jan 12;11(1):598. doi: 10.1038/s41598-020-79893-9.
The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determined to be low at therapeutically-relevant concentrations. Selected Gd(III) complexes are potential candidates for further investigation as theranostic agents.
描述了一系列新型 Gd(III)-芳基膦配合物的合成，并报告了所选化合物的溶液稳定性。介绍了它们在人神经胶质（SVG p12）和人多形性胶质母细胞瘤（T98G）细胞系中的亲脂性和摄取情况。所有配合物在治疗相关浓度下的体外细胞毒性均较低。选定的 Gd(III)配合物可能是作为治疗诊断试剂进一步研究的候选物。
Zotero 插件