Department of Chemistry, Arak Branch, Islamic Azad University, Arak, Iran.
Department of Chemical Sciences, Bernal Institute, Synthesis and Solid-State Pharmaceutical Centre (SSPC), University of Limerick, Limerick, Ireland.
Sci Rep. 2021 Jan 12;11(1):535. doi: 10.1038/s41598-020-79983-8.
In the pharmaceutical manufacturing, drug release behavior development is remained as one of the main challenges to improve the drug effectiveness. Recently, more focus has been done on using mesoporous silica materials as drug carriers for prolonged and superior control of drug release in human body. In this study, release behavior of paracetamol is developed using drug-loaded KCC-1-NH mesoporous silica, based on direct compaction method for preparation of tablets. The purpose of this study is to investigate the utilizing of pure KCC-1 mesoporous silica (KCC-1) and amino functionalized KCC-1 (KCC-1-NH) as drug carriers in oral solid dosage formulations compared to common excipient, microcrystalline cellulose (MCC), to improve the control of drug release rate by manipulating surface chemistry of the carrier. Different formulations of KCC-1 and KCC-NH are designed to investigate the effect of functionalized mesoporous silica as carrier on drug controlled-release rate. The results displayed the remarkable effect of KCC-1-NH on drug controlled-release in comparison with the formulation containing pure KCC-1 and formulation including MCC as reference materials. The pure KCC-1 and KCC-1-NH are characterized using different evaluation methods such as FTIR, SEM, TEM and N adsorption analysis.
在制药生产中，开发药物释放行为仍然是提高药物疗效的主要挑战之一。最近，人们越来越关注将介孔硅材料用作药物载体，以在人体内实现更持久和更优异的药物释放控制。在这项研究中，我们使用载药 KCC-1-NH 介孔硅通过直接压实法制备片剂来开发扑热息痛的释放行为。本研究的目的是研究将纯 KCC-1 介孔硅 (KCC-1) 和氨基功能化 KCC-1 (KCC-1-NH) 用作口服固体制剂中的药物载体，与普通赋形剂微晶纤维素 (MCC) 相比，通过操纵载体的表面化学来改善药物释放速率的控制。设计了不同的 KCC-1 和 KCC-NH 配方，以研究功能化介孔硅作为载体对药物控制释放速率的影响。结果显示，与包含纯 KCC-1 的配方和包含 MCC 的配方作为参考材料的配方相比，KCC-1-NH 对药物控制释放具有显著影响。使用不同的评估方法，如 FTIR、SEM、TEM 和 N 吸附分析，对纯 KCC-1 和 KCC-1-NH 进行了表征。
