Mater Mahnashi H, Mahmoud Ashraf M, Saad Alkahtani A, El-Wekil Mohamed M
Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Microchem J. 2021 Apr;163:105925. doi: 10.1016/j.microc.2021.105925. Epub 2021 Jan 8.
In this research paper, an innovative electrochemical sensor was suggested for simultaneous voltammetric analysis of azithromycin (AZM) and hydroxychloroquine (HCQ) for the first time. The sensor based on hydrothermal synthesis of vanadium disulfide quantum dots (VS QDs) and insertion within 3D N, S graphene aerogel (3D N, S @ GNA) and carbon nanotubes nanaostructure as a new and widely group of carbon nanomaterials. The nanocomposites were characterized morphologically using different techniques. In addition, the nanomaterials were characterized electrochemically using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). The proposed electrochemical sensor showed wide dynamic linear ranges of 0.28-30 × 10 M and 0.84-22.5 × 10 M for analysis of AZM and HCQ, respectively. The limits of detection (LODs) based on signal to noise (S/N) 3:1 were found to be 0.091 × 10 M and 0.277 × 10 M for AZM and HCQ, respectively. Briefly, the electrochemical sensor had good stability, selectivity, reproducibility and feasibility for simultaneous detection of AZM and HCQ in presence of different interfering species.
在本研究论文中，首次提出了一种创新的电化学传感器，用于同时伏安法分析阿奇霉素（AZM）和羟氯喹（HCQ）。该传感器基于水热合成二硫化钒量子点（VS QDs）并将其插入三维氮、硫石墨烯气凝胶（3D N，S @ GNA）和碳纳米管纳米结构中，碳纳米管是一种新型且应用广泛的碳纳米材料。使用不同技术对纳米复合材料进行了形态表征。此外，使用循环伏安法（CV）、电化学阻抗谱（EIS）和差分脉冲伏安法（DPV）对纳米材料进行了电化学表征。所提出的电化学传感器在分析AZM和HCQ时分别显示出0.28 - 30×10 M和0.84 - 22.5×10 M的宽动态线性范围。基于信噪比（S/N）3:1的检测限（LOD）分别为AZM的0.091×10 M和HCQ的0.277×10 M。简而言之，该电化学传感器在存在不同干扰物质的情况下，对同时检测AZM和HCQ具有良好的稳定性、选择性、重现性和可行性。
