Mostafazadeh Reza, Karimi-Maleh Hassan, Ghaffarinejad Ali, Tajabadi Fariba, Hamidian Yasamin
Research Laboratory of Real Samples Analysis, Faculty of Chemistry, Iran University of Science and Technology (IUST), Tehran, 1684613114 Iran.
Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, PO Box 31787-316, Karaj, Iran.
Appl Nanosci. 2023 Jan 24:1-10. doi: 10.1007/s13204-023-02773-x.
In this report, Azithromycin (Azi) antibiotic was measured by carbon paste electrode (CPE) improved by graphene nanoribbon-CoFeO@NiO nanocomposite and 1-hexyl-3 methylimidazolium hexafluorophosphate (HMIM PF) as an ionic liquid binder. The electrochemical behavior of Azi on the graphene nanoribbon-CoFeO@NiO/HMIM PF/CPE is investigated by voltammetric methods, and the results showed that the modifiers improve the conductivity and electrochemical activity of the CPE. According to obtained data, the electrochemical behavior of Azi is related to pH. under optimum conditions, the sensor has linear ranges from 10 µM to 2 mM with a LOD of 0.66 µM. The effect of scan rate and chronoamperometry were studied, which showed that the Azi electro-oxidation is diffusion controlled with the diffusion coefficient of 9.22 × 10 cm/s. The reproducibility (3.15%), repeatability (2.5%), selectivity, and stability (for 30 days) tests were investigated, which results were acceptable. The actual sample analysis confirmed that the proposed sensor is an appropriate electrochemical tool for Azi determination in urine and Azi capsule.
在本报告中，采用石墨烯纳米带 - CoFeO@NiO纳米复合材料和1 - 己基 - 3 - 甲基咪唑六氟磷酸盐（HMIM PF）作为离子液体粘合剂改进的碳糊电极（CPE）来测定阿奇霉素（Azi）抗生素。通过伏安法研究了Azi在石墨烯纳米带 - CoFeO@NiO/HMIM PF/CPE上的电化学行为，结果表明改性剂提高了CPE的导电性和电化学活性。根据所得数据，Azi的电化学行为与pH有关。在最佳条件下，该传感器的线性范围为10 µM至2 mM，检测限为0.66 µM。研究了扫描速率和计时电流法的影响，结果表明Azi的电氧化受扩散控制，扩散系数为9.22×10 cm/s。进行了重现性（3.15%）、重复性（2.5%）、选择性和稳定性（30天）测试，结果均可接受。实际样品分析证实，所提出的传感器是用于测定尿液和Azi胶囊中Azi的合适电化学工具。
